Mucin directed lipsome
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United States of America Patent
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-
May 1, 1990
Grant Date -
N/A
app pub date -
Feb 29, 1988
filing date -
Feb 29, 1988
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Mucin coated Sepharose is used as a laboratory model to measure the affinity of a postulated lipid composition in liposome configuration for binding to mucin. The preferred lipid composition provides a first lipid moiety which projects a postive charged ion. A second lipid moiety enhances the positive charge by neutralizing all intermediate negative charges of the first lipid. The result is a liposome with strong postive charge areas which will bind to mucin.
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