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Abstract

Disclosed is a cardiac biopotential analysis system and method for detecting, in a noninvasive manner, the degree of myocardial ischemia and the amount of cardiac electrophysiologic stability present in a subject. A suitable body surface electrode acquires the signal from a region of interest. The body surface electrocardiographic signals are then amplified, digitized and transmitted to a host computer where an arrhythmia free QRST complex template is chosen interactively. Using cross-correlation, 50 subsequent complexes that mask the template are extracted. A Fast Fourier Transform (FFT) is then performed on every beat. The FFT results of every QRST are used to produce a bispectral complex and real triple product arrays. Each point in these arrays is then averaged over the 50 previously acquired QRST complexes. The magnitude of each averaged point in the complex triple product arrays is then squared to produce a bispectral density array, which when divided by the complex real triple product array forms a bicoherence array. The bicoherence array provides a figure of merit for the detection and quantification of myocardial ischemia in the region probed by that lead. The array also provides a quantification of cardiac electrical properties.

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