US Patent No: 4,926,852

Number of patents in Portfolio can not be more than 2000

Medication delivery system phase one

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Abstract

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An apparatus for use in inhaling pharmaceutical aerosols. The apparatus includes a mouthpiece and a rigid housing for receiving an aerosolized medicine. The rigid housing has one or more orifices which are spaced from the mouth piece so that flow through the housing is possible but is limited by the orifice(s) to a desired volumetric flow rate. The patient is aided by having the initial velocity of the aerosolized medicine reduced to zero by virtue of the initial delivery of the same to the housing interior, and by having the volumetric flow rate of the inhaled medication maintained below required limits thereby providing the conditions for optimal dosing. Further, the ability of the patient to inhale to total lung capacity with the flow through chamber enhances penetration of aerosolized drug to the lung periphery, and improves the ease of use for the patient.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE JOHNS HOPKINS UNIVERSITYBALTIMORE, MD1641

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adams, III George K Baltimore, MD 3 461
Laube, Beth L Baltimore, MD 4 585
Zoltan, Bart J Old Tappan, NJ 11 746

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MAZDA MOTOR CORPORATION (1)
4,919,097 Engine output control system 23 1988
 
Trudell Medical Limited (2)
4,534,343 Metered dose inhaler 144 1984
4,796,614 Collapsible inhalation valve 64 1987
 
Key Pharmaceuticals, Incorporated (1)
4,484,577 Drug delivery method and inhalation device therefor 177 1982
 
HEALTH CARE CONCEPTS (1)
4,612,926 Dual-range aspirator device 13 1985
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
SP MEDICAL LLC (3)
6,453,900 Inhaler device 4 2000
6,523,536 Dual-canister inhaler having a spacer and easy to operate lever mechanism 34 2001
6,698,422 Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece 19 2002
 
Other [Check patent profile for assignment information] (6)
* 5,178,138 Drug delivery device 228 1990
* 5,752,502 General purpose aerosol inhalation apparatus 60 1993
* 5,477,849 Spacer for medication inhaler 37 1994
* 5,809,996 Collapsible metered dose inhaler 27 1996
* 2004/0241,800 Vascular endothelial growth factor dimers 1 2003
* 2009/0285,905 SYSTEMS AND PROCESSES FOR SPRAY DRYING HYDROPHOBIC DRUGS WITH HYDROPHILIC EXCIPIENTS 6 2009
 
NOVARTIS AG (10)
8,408,200 Flow resistance modulated aerosolized active agent delivery 10 1999
* 2002/0168,322 FLOW RESISTANCE MODULATED AEROSOLIZED ACTIVE AGENT DELIVERY 3 1999
7,097,827 Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments 11 2002
* 2003/0068,279 Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments 3 2002
7,138,141 Dispersible macromolecule compositions and methods for their preparation and use 17 2003
* 2003/0215,514 Dispersible macromolecule compositions and methods for their preparation and use 8 2003
7,521,069 Methods and compositions for pulmonary delivery of insulin 31 2003
8,161,969 Dry powder dispersing apparatus and methods for their use 1 2008
* 2008/0230,058 Dry powder dispersing apparatus and methods for their use 2 2008
8,337,895 Spray drying process control of drying kinetics 0 2009
 
NEKTAR THERAPEUTICS (2)
8,273,330 Particulate materials 1 2003
* 2003/0232,020 Particulate materials 4 2003
 
NOVARTIS PHARMA AG (34)
* 5,458,135 Method and device for delivering aerosolized medicaments 265 1992
* 5,775,320 Method and device for delivering aerosolized medicaments 137 1995
* 5,780,014 Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin 65 1996
* 6,051,256 Dispersible macromolecule compositions and methods for their preparation and use 128 1996
6,685,967 Methods and compositions for pulmonary delivery of insulin 48 1996
* 5,997,848 Methods and compositions for pulmonary delivery of insulin 165 1997
* 6,138,668 Method and device for delivering aerosolized medicaments 71 1997
* 5,993,783 Method and apparatus for pulmonary administration of dry powder .alpha.1-antitrypsin 51 1998
* 6,655,379 Aerosolized active agent delivery 60 1999
6,509,006 Devices compositions and methods for the pulmonary delivery of aerosolized medicaments 42 1999
6,423,344 Dispersible macromolecule compositions and methods for their preparation and use 80 2000
6,681,767 Method and device for delivering aerosolized medicaments 47 2000
6,606,992 Systems and methods for aerosolizing pharmaceutical formulations 58 2000
6,543,448 Apparatus and methods for dispersing dry powder medicaments 75 2000
6,546,929 Dry powder dispersing apparatus and methods for their use 33 2001
6,592,904 Dispersible macromolecule compositions and methods for their preparation and use 71 2001
6,797,258 Compositions and methods for the pulmonary delivery of aerosolized macromolecules 32 2002
6,737,045 Methods and compositions for the pulmonary delivery insulin 40 2002
* 2002/0192,164 Methods and compositions for the pulmonary delivery insulin 14 2002
6,901,929 Dry powder dispersing apparatus and methods for their use 10 2002
* 2003/0209,243 Dry powder dispersing apparatus and methods for their use 1 2002
6,921,527 Composition for pulmonary administration comprising a drug and a hydrophobic amino acid 47 2003
* 2003/0129,141 Composition for pulmonary administration comprising a drug and a hydrophobic amino acid 3 2003
7,185,651 Flow regulator for aerosol drug delivery and methods 6 2003
* 2004/0000,309 Flow regulator for aerosol drug delivery and methods 0 2003
* 2005/0016,533 Systems and methods for aerosolizing pharmaceutical formulations 9 2003
* 2005/0090,798 Aerosolized active agent delivery 6 2003
* 2005/0279,349 Method and device for delivering aerosolized medicaments 0 2003
7,422,013 Dry powder dispersing apparatus and methods for their use 19 2005
* 2007/0042,048 Devices, Compositions and Methods for the Pulmonary Delivery of Aerosolized Medicaments 1 2006
8,173,168 Dispersible macromolecule compositions and methods for their preparation and use 0 2006
* 2007/0020,199 DISPERSIBLE MACROMOLECULE COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE 4 2006
8,802,149 Systems and processes for spray drying hydrophobic and hydrophilic components 1 2009
* 2010/0034,910 Spray drying process control of drying kinetics 1 2009
 
VENTAIRA PHARMACEUTICALS, INC. (1)
6,705,316 Pulmonary dosing system and method 58 2002
 
KOS LIFE SCIENCES, INC. (3)
6,418,925 Low spray force, low retention atomization system 21 2000
6,595,204 Spacer for an inhaler 5 2001
6,567,686 Method for improving lung delivery of pharmaceutical aerosols 16 2001
 
VECTURA GMBH (1)
D742503 Mobile inhaler device 0 2013
 
RAPTOR PHARMACEUTICAL INC. (13)
8,815,838 Aerosol fluoroquinolone formulations for improved pharmacokinetics 1 2009
8,629,139 Topical use of Levofloxacin for reducing lung inflammation 1 2009
* 2010/0087,416 AEROSOL FLUOROQUINOLONE FORMULATIONS FOR IMPROVED PHARMACOKINETICS 7 2009
* 2010/0087,386 TOPICAL USE OF LEVOFLOXACIN FOR REDUCING LUNG INFLAMMATION 2 2009
8,546,423 Aerosolized fluoroquinolones and uses thereof 1 2009
8,524,734 Aerosolized fluoroquinolones and uses thereof 1 2009
8,524,735 Aerosolized fluoroquinolones and uses thereof 1 2009
* 2010/0166,673 AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF 3 2009
* 2010/0040,560 AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF 1 2009
* 2010/0037,890 AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF 0 2009
8,357,696 Aerosolized fluoroquinolones and uses thereof 1 2010
* 2010/0158,957 AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF 2 2010
9,326,936 Aerosol fluoroquinolone formulations for improved pharmacokinetics 0 2014
 
MICRODOSE THERAPEUTX, INC. (1)
* 2008/0228,099 ADAPTORS FOR INHALERS TO IMPROVE PERFORMANCE 1 2008
 
Pediatric Innovations USA, LLC (4)
D701956 Nasal device 2 2013
D701599 Nasal device 3 2013
D732658 Nasal device with airplane wings 0 2014
D732659 Car-shaped nasal device 0 2014
 
TUNITAS THERAPEUTICS, INC. (2)
8,961,992 Epsigam fusion protein 0 2014
9,109,030 Epsigam fusion protein 0 2015
 
MEF MEDICINE, INC. (1)
D618335 Nasal device 6 2009
 
Thayer Medical Corporation (1)
D362500 Medication inhaler spacer 26 1994
 
Scios, Inc. (3)
6,475,796 Vascular endothelial growth factor variants 13 2000
6,887,848 Vascular endothelial growth factor variants 2 2002
* 2005/0119,165 Vascular endothelial growth factor dimers 6 2004
 
MIRIS MEDICAL INCORPORATED, A CORP. OF CA (1)
* 5,404,871 Delivery of aerosol medications for inspiration 357 1991
 
BECTON, DICKINSON AND COMPANY (2)
8,413,651 Disposable spacer for inhalation delivery of aerosolized drugs and vaccines 1 2008
* 2010/0163,045 DISPOSABLE SPACER FOR INHALATION DELIVERY OF AEROSOLIZED DRUGS AND VACCINES 1 2008
 
ASTRAZENECA AB (6)
6,794,357 Compositions for inhalation 18 1996
6,632,456 Compositions for inhalation 14 1997
6,846,801 Systemic administration of a therapeutic preparation 2 1998
6,610,653 Therapeutic preparation for inhalation 2 2000
* 2003/0216,541 Systemic administration of a therapeutic preparation 2 2003
* 2003/0211,972 Systemic administration of a therapeutic preparation 2 2003
 
PROFILE DRUG DELIVERY LIMITED (1)
6,779,521 Combination mouthpiece for inhalation therapy devices used by oxygen dependent patients 1 2002
 
The Regents of the University of California (2)
7,488,804 Modified fusion molecules for treatment of allergic disease 5 2005
* 2006/0171,942 Modified fusion molecules for treatment of allergic disease 3 2005
 
3M INNOVATIVE PROPERTIES COMPANY (1)
6,615,826 Slow spray metered dose inhaler 17 2000
 
Mankind Corporation (1)
9,192,675 Dry powder inhaler and system for drug delivery 0 2013
 
QUADRANT DRUG DELIVERY LIMITED (3)
7,785,631 Solid dose delivery vehicle and methods of making same 7 2005
7,780,991 Solid dose delivery vehicle and methods of making same 3 2005
7,744,925 Solid dose delivery vehicle and methods of making same 5 2005
 
PHILIP MORRIS USA INC. (24)
6,557,552 Aerosol generator and methods of making and using an aerosol generator 57 2000
6,701,921 Aerosol generator having heater in multilayered composite and method of use thereof 36 2000
6,681,998 Aerosol generator having inductive heater and method of use thereof 27 2000
6,501,052 Aerosol generator having multiple heating zones and methods of use thereof 54 2000
6,491,233 Vapor driven aerosol generator and method of use thereof 41 2000
6,640,050 Fluid vaporizing device having controlled temperature profile heater/capillary tube 36 2001
6,568,390 Dual capillary fluid vaporizing device 72 2001
6,883,516 Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution 26 2001
6,804,458 Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate 18 2001
6,681,769 Aerosol generator having a multiple path heater arrangement and method of use thereof 28 2001
7,077,130 Disposable inhaler system 28 2001
* 2002/0078,951 Disposable aerosol generator system and methods for administering the aerosol 4 2001
6,701,922 Mouthpiece entrainment airflow control for aerosol generators 110 2001
7,173,222 Aerosol generator having temperature controlled heating zone and method of use thereof 26 2002
7,128,067 Method and apparatus for generating an aerosol 28 2003
* 2004/0016,427 Method and apparatus for generating an aerosol 10 2003
6,715,487 Dual capillary fluid vaporizing device 66 2003
7,117,867 Aerosol generator and methods of making and using an aerosol generator 38 2003
* 2004/0050,383 Aerosol generator and methods of making and using an aerosol generator 7 2003
7,367,334 Fluid vaporizing device having controlled temperature profile heater/capillary tube 13 2003
* 2004/0182,389 Aerosol generator having heater in multilayered composite and method of use thereof 1 2003
* 2004/0170,405 Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate 5 2004
7,373,938 Disposable aerosol generator system and methods for administering the aerosol 20 2004
7,163,014 Disposable inhaler system 22 2004
 
Healthscan Products, Inc. (1)
* 5,297,543 Medication inhaler mixer 33 1992
 
CHARLES RIVER LABORATORIES, INC. (1)
* 6,725,859 Apparatus for delivering air-borne substances 6 1998
 
GLAXO GROUP LIMITED (1)
* 5,427,089 Valved auxiliary device for use with aerosol container 63 1993
 
ASTRA AKTLEBOLAG (2)
6,932,962 Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides 21 1995
* 6,524,557 Aerosol formulations of peptides and proteins 36 1996
 
ACTIVAERO GMBH (1)
D697200 Mobile inhaler device 3 2011
 
MANNKIND CORPORATION (13)
7,464,706 Unit dose cartridge and dry powder inhaler 35 2003
* 2004/0182,387 Unit dose cartridge and dry powder inhaler 41 2003
* 2009/0241,949 DRY POWDER INHALATION SYSTEM 23 2009
9,364,619 Interactive apparatus and method for real-time profiling of inhalation efforts 0 2009
9,061,111 Unit dose capsules and dry powder inhaler 0 2012
8,671,937 Unit dose capsules and dry powder inhaler 8 2012
8,950,397 Unit dose cartridge and dry powder inhaler 0 2012
9,364,436 High capacity diketopiperazine microparticles and methods 0 2012
9,339,615 Dry powder inhaler and system for drug delivery 0 2013
9,241,903 Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent 0 2013
9,283,193 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 0 2014
9,346,766 Catalysis of diketopiperazine synthesis 0 2014
9,220,687 Substituted diketopiperazine analogs for use as drug delivery agents 0 2014
 
Fisons plc (1)
* 5,239,991 Disposable powder medicament inhalation device with peel-off cover 42 1992
 
BAXTER INTERNATIONAL INC. (3)
8,672,876 Fluid delivery system and flow control therefor 1 2008
8,231,566 Fluid delivery system and flow control therefor 1 2008
8,226,597 Fluid delivery system and flow control therefor 2 2008
 
ARADIGM CORPORATION (61)
* 5,450,336 Method for correcting the drift offset of a transducer 68 1993
* 5,394,866 Automatic aerosol medication delivery system and methods 159 1993
* 5,392,768 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 146 1993
* 5,709,202 Intrapulmonary delivery of aerosolized formulations 106 1993
* 5,497,763 Disposable package for intrapulmonary delivery of aerosolized formulations 51 1993
* 5,544,646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 205 1994
* 5,509,404 Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values 204 1994
* 5,672,581 Method of administration of insulin 76 1994
* 5,558,085 Intrapulmonary delivery of peptide drugs 32 1994
* 5,542,410 Delivery of aeerosol medications for inspiration 76 1994
* 5,622,162 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 82 1995
* 5,497,764 Medication cassette for an automatic aerosol medication delivery 52 1995
* 5,520,166 Medication cassette for an automatic aerosol medication delivery system 157 1995
* 5,718,222 Disposable package for use in aerosolized delivery of drugs 114 1995
* 5,724,957 Intrapulmonary delivery of narcotics 182 1995
* 5,608,647 Method for releasing controlled amount of aerosol medication 189 1995
* 6,098,620 Device for aerosolizing narcotics 76 1995
* 5,960,792 Device for aerosolized delivery of peptide drugs 189 1995
* 5,934,272 Device and method of creating aerosolized mist of respiratory drug 244 1995
* 5,915,378 Creating an aerosolized formulation of insulin 145 1995
* 5,655,516 Delivery of aerosol medications for inspiration 53 1996
* 6,012,450 Intrapulmonary delivery of hematopoietic drug 150 1996
* 5,823,178 Disposable package for use in aerosolized delivery of drugs 90 1996
* 5,743,250 Insulin delivery enhanced by coached breathing 143 1996
* 5,755,218 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 151 1996
* 5,743,252 Method for releasing controlled amount of aerosol medication 74 1996
* 5,888,477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 54 1997
* 5,819,726 Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease 29 1997
* 5,826,570 Delivery of aerosol medications for inspiration 64 1997
* 5,884,620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 65 1997
* 6,131,567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 56 1998
* 6,085,753 Insulin delivery enhanced by coached breathing 37 1998
* 6,123,068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 64 1998
* 6,098,615 Method of reproducibly effecting a patient's glucose level 37 1998
* 5,970,973 Method of delivering insulin lispro 59 1998
* 5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range 17 1998
* 6,024,090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 17 1998
* 5,941,240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 49 1998
* 6,014,969 Disposable package for use in aerosolized delivery of antibiotics 40 1998
6,167,880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 66 1999
6,408,854 Insulin delivery enhanced by coached breathing 31 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 39 2000
6,551,542 Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs 1 2000
6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 25 2001
* 2002/0124,852 Method of treating diabetes mellitus in a patient 4 2001
6,427,681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
6,688,304 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 12 2001
6,431,167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 9 2001
6,647,987 Insulin delivery enhanced by coached breathing 3 2002
7,021,309 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 3 2003
* 2004/0062,722 Method of use of monomeric insulin as a means for improving the reproducibilty of inhaled insulin 12 2003
7,028,686 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 25 2003
* 2004/0089,290 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 0 2003
7,278,419 Method for treating diabetes mellitus in a patient 15 2004
7,448,375 Method of treating diabetes mellitus in a patient 16 2005
* 2005/0274,377 Method of treating diabetes mellitus in a patient 4 2005
7,490,603 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 1 2005
* 2006/0093,556 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 57 2005
* 2006/0124,125 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 2 2006
* 2008/0099,011 INHALED INSULIN DOSAGE CONTROL DELIVERY ENHANCED BY CONTROLLING TOTAL INHALED VOLUME 5 2007
* 2008/0264,416 Method of Treating Diabetes Mellitus in a Patient 2 2008
 
TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (1)
9,233,159 Methods and compositions for treating pain 0 2012
 
FSC LABORATORIES, INC. (1)
* 5,318,016 Inhalation device 21 1993
 
DEX MEDIA, INC. (1)
6,516,796 Aerosol generator and methods of making and using an aerosol generator 67 2000
* Cited By Examiner