Medication delivery system phase one

Number of patents in Portfolio can not be more than 2000

United States of America Patent

SERIAL NO

07251454

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

An apparatus for use in inhaling pharmaceutical aerosols. The apparatus includes a mouthpiece and a rigid housing for receiving an aerosolized medicine. The rigid housing has one or more orifices which are spaced from the mouth piece so that flow through the housing is possible but is limited by the orifice(s) to a desired volumetric flow rate. The patient is aided by having the initial velocity of the aerosolized medicine reduced to zero by virtue of the initial delivery of the same to the housing interior, and by having the volumetric flow rate of the inhaled medication maintained below required limits thereby providing the conditions for optimal dosing. Further, the ability of the patient to inhale to total lung capacity with the flow through chamber enhances penetration of aerosolized drug to the lung periphery, and improves the ease of use for the patient.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
THE JOHNS HOPKINS UNIVERSITYBALTIMORE, MD1851

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adams, III George K Baltimore, MD 3 513
Laube, Beth L Baltimore, MD 4 656
Zoltan, Bart J Old Tappan, NJ 11 809

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MAZDA MOTOR CORPORATION (1)
4919097 Engine output control system 23 1988
 
TRUDELL MEDICAL LIMITED (2)
4534343 Metered dose inhaler 153 1984
4796614 Collapsible inhalation valve 72 1987
 
Key Pharmaceuticals, Inc. (1)
4484577 Drug delivery method and inhalation device therefor 195 1982
 
HEALTH CARE CONCEPTS (1)
4612926 Dual-range aspirator device 14 1985
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
SP MEDICAL LLC (3)
6453900 Inhaler device 4 2000
6523536 Dual-canister inhaler having a spacer and easy to operate lever mechanism 52 2001
6698422 Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece 37 2002
 
Other [Check patent profile for assignment information] (6)
* 5178138 Drug delivery device 248 1990
* 5752502 General purpose aerosol inhalation apparatus 62 1993
* 5477849 Spacer for medication inhaler 42 1994
* 5809996 Collapsible metered dose inhaler 27 1996
* 2004/0241,800 Vascular endothelial growth factor dimers 1 2003
* 2009/0285,905 SYSTEMS AND PROCESSES FOR SPRAY DRYING HYDROPHOBIC DRUGS WITH HYDROPHILIC EXCIPIENTS 10 2009
 
NOVARTIS AG (10)
8408200 Flow resistance modulated aerosolized active agent delivery 29 1999
* 2002/0168,322 FLOW RESISTANCE MODULATED AEROSOLIZED ACTIVE AGENT DELIVERY 7 1999
7097827 Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments 14 2002
* 2003/0068,279 Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments 4 2002
7138141 Dispersible macromolecule compositions and methods for their preparation and use 21 2003
* 2003/0215,514 Dispersible macromolecule compositions and methods for their preparation and use 11 2003
7521069 Methods and compositions for pulmonary delivery of insulin 48 2003
8161969 Dry powder dispersing apparatus and methods for their use 1 2008
* 2008/0230,058 Dry powder dispersing apparatus and methods for their use 2 2008
8337895 Spray drying process control of drying kinetics 1 2009
 
NEKTAR THERAPEUTICS (3)
8273330 Particulate materials 2 2003
* 2003/0232,020 Particulate materials 5 2003
9700529 Particulate materials 0 2016
 
INHALE THERAPEUTIC SYSTEMS, INC. (1)
* 2005/0016,533 Systems and methods for aerosolizing pharmaceutical formulations 11 2003
 
NOVARTIS PHARMA AG (33)
* 5458135 Method and device for delivering aerosolized medicaments 295 1992
* 5775320 Method and device for delivering aerosolized medicaments 164 1995
* 5780014 Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin 72 1996
* 6051256 Dispersible macromolecule compositions and methods for their preparation and use 156 1996
6685967 Methods and compositions for pulmonary delivery of insulin 69 1996
* 5997848 Methods and compositions for pulmonary delivery of insulin 191 1997
* 6138668 Method and device for delivering aerosolized medicaments 74 1997
* 5993783 Method and apparatus for pulmonary administration of dry powder .alpha.1-antitrypsin 55 1998
* 6655379 Aerosolized active agent delivery 81 1999
6509006 Devices compositions and methods for the pulmonary delivery of aerosolized medicaments 58 1999
6423344 Dispersible macromolecule compositions and methods for their preparation and use 102 2000
6681767 Method and device for delivering aerosolized medicaments 69 2000
6606992 Systems and methods for aerosolizing pharmaceutical formulations 75 2000
6543448 Apparatus and methods for dispersing dry powder medicaments 103 2000
6546929 Dry powder dispersing apparatus and methods for their use 48 2001
6592904 Dispersible macromolecule compositions and methods for their preparation and use 99 2001
6797258 Compositions and methods for the pulmonary delivery of aerosolized macromolecules 50 2002
6737045 Methods and compositions for the pulmonary delivery insulin 57 2002
* 2002/0192,164 Methods and compositions for the pulmonary delivery insulin 16 2002
6901929 Dry powder dispersing apparatus and methods for their use 11 2002
* 2003/0209,243 Dry powder dispersing apparatus and methods for their use 1 2002
6921527 Composition for pulmonary administration comprising a drug and a hydrophobic amino acid 59 2003
* 2003/0129,141 Composition for pulmonary administration comprising a drug and a hydrophobic amino acid 6 2003
7185651 Flow regulator for aerosol drug delivery and methods 7 2003
* 2004/0000,309 Flow regulator for aerosol drug delivery and methods 0 2003
* 2005/0090,798 Aerosolized active agent delivery 7 2003
* 2005/0279,349 Method and device for delivering aerosolized medicaments 4 2003
7422013 Dry powder dispersing apparatus and methods for their use 34 2005
* 2007/0042,048 Devices, Compositions and Methods for the Pulmonary Delivery of Aerosolized Medicaments 1 2006
8173168 Dispersible macromolecule compositions and methods for their preparation and use 2 2006
* 2007/0020,199 DISPERSIBLE MACROMOLECULE COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE 5 2006
8802149 Systems and processes for spray drying hydrophobic and hydrophilic components 1 2009
* 2010/0034,910 Spray drying process control of drying kinetics 1 2009
 
VENTAIRA PHARMACEUTICALS, INC. (1)
6705316 Pulmonary dosing system and method 73 2002
 
KOS LIFE SCIENCES, INC. (3)
6418925 Low spray force, low retention atomization system 23 2000
6595204 Spacer for an inhaler 5 2001
6567686 Method for improving lung delivery of pharmaceutical aerosols 31 2001
 
HORIZON ORPHAN LLC (15)
8815838 Aerosol fluoroquinolone formulations for improved pharmacokinetics 3 2009
8629139 Topical use of Levofloxacin for reducing lung inflammation 3 2009
* 2010/0087,416 AEROSOL FLUOROQUINOLONE FORMULATIONS FOR IMPROVED PHARMACOKINETICS 14 2009
* 2010/0087,386 TOPICAL USE OF LEVOFLOXACIN FOR REDUCING LUNG INFLAMMATION 6 2009
8546423 Aerosolized fluoroquinolones and uses thereof 3 2009
8524734 Aerosolized fluoroquinolones and uses thereof 3 2009
8524735 Aerosolized fluoroquinolones and uses thereof 3 2009
* 2010/0166,673 AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF 6 2009
* 2010/0040,560 AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF 3 2009
* 2010/0037,890 AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF 0 2009
8357696 Aerosolized fluoroquinolones and uses thereof 3 2010
* 2010/0158,957 AEROSOLIZED FLUOROQUINOLONES AND USES THEREOF 5 2010
9700564 Use of aerosolized levofloxacin for treating cystic fibrosis 0 2012
9326936 Aerosol fluoroquinolone formulations for improved pharmacokinetics 1 2014
9717738 Aerosol fluoroquinolone formulations for improved pharmacokinetics 0 2016
 
VECTURA GMBH (1)
D742503 Mobile inhaler device 5 2013
 
MICRODOSE THERAPEUTX, INC. (1)
* 2008/0228,099 ADAPTORS FOR INHALERS TO IMPROVE PERFORMANCE 1 2008
 
Pediatric Innovations USA, LLC (4)
D701956 Nasal device 2 2013
D701599 Nasal device 3 2013
D732658 Nasal device with airplane wings 0 2014
D732659 Car-shaped nasal device 0 2014
 
TUNITAS THERAPEUTICS, INC. (2)
8961992 Epsigam fusion protein 0 2014
9109030 Epsigam fusion protein 0 2015
 
MEF MEDICINE, INC. (1)
D618335 Nasal device 6 2009
 
Thayer Medical Corporation (1)
D362500 Medication inhaler spacer 40 1994
 
TORREY PINES INSTITUTE OF MOLECULAR STUDIES (1)
9610351 Methods and compositions for treating pain 0 2015
 
Scios, Inc. (3)
6475796 Vascular endothelial growth factor variants 13 2000
6887848 Vascular endothelial growth factor variants 2 2002
* 2005/0119,165 Vascular endothelial growth factor dimers 7 2004
 
MIRIS MEDICAL INCORPORATED, A CORP. OF CA (1)
* 5404871 Delivery of aerosol medications for inspiration 399 1991
 
ASTRAZENECA AB (7)
6794357 Compositions for inhalation 21 1996
6632456 Compositions for inhalation 29 1997
6846801 Systemic administration of a therapeutic preparation 2 1998
6610653 Therapeutic preparation for inhalation 2 2000
* 2003/0216,541 Systemic administration of a therapeutic preparation 2 2003
* 2003/0211,972 Systemic administration of a therapeutic preparation 3 2003
* 2004/0171,550 Compositions for inhalation 7 2004
 
BECTON, DICKINSON AND COMPANY (2)
8413651 Disposable spacer for inhalation delivery of aerosolized drugs and vaccines 1 2008
* 2010/0163,045 DISPOSABLE SPACER FOR INHALATION DELIVERY OF AEROSOLIZED DRUGS AND VACCINES 1 2008
 
PROFILE DRUG DELIVERY LIMITED (1)
6779521 Combination mouthpiece for inhalation therapy devices used by oxygen dependent patients 5 2002
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (2)
7488804 Modified fusion molecules for treatment of allergic disease 6 2005
* 2006/0171,942 Modified fusion molecules for treatment of allergic disease 4 2005
 
3M INNOVATIVE PROPERTIES COMPANY (1)
6615826 Slow spray metered dose inhaler 23 2000
 
Mankind Corporation (1)
9192675 Dry powder inhaler and system for drug delivery 0 2013
 
QUADRANT DRUG DELIVERY LIMITED (3)
7785631 Solid dose delivery vehicle and methods of making same 13 2005
7780991 Solid dose delivery vehicle and methods of making same 4 2005
7744925 Solid dose delivery vehicle and methods of making same 13 2005
 
BOEHRINGER INGELHEIM INTERNATIONAL GMBH (1)
* 9533112 Inhaler 0 2008
 
Philip Morris USA Inc. (25)
6516796 Aerosol generator and methods of making and using an aerosol generator 77 2000
6557552 Aerosol generator and methods of making and using an aerosol generator 68 2000
6701921 Aerosol generator having heater in multilayered composite and method of use thereof 46 2000
6681998 Aerosol generator having inductive heater and method of use thereof 33 2000
6501052 Aerosol generator having multiple heating zones and methods of use thereof 67 2000
6491233 Vapor driven aerosol generator and method of use thereof 46 2000
6640050 Fluid vaporizing device having controlled temperature profile heater/capillary tube 53 2001
6568390 Dual capillary fluid vaporizing device 94 2001
6883516 Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution 29 2001
6804458 Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate 23 2001
6681769 Aerosol generator having a multiple path heater arrangement and method of use thereof 34 2001
7077130 Disposable inhaler system 43 2001
* 2002/0078,951 Disposable aerosol generator system and methods for administering the aerosol 6 2001
6701922 Mouthpiece entrainment airflow control for aerosol generators 119 2001
7173222 Aerosol generator having temperature controlled heating zone and method of use thereof 38 2002
7128067 Method and apparatus for generating an aerosol 44 2003
* 2004/0016,427 Method and apparatus for generating an aerosol 14 2003
6715487 Dual capillary fluid vaporizing device 94 2003
7117867 Aerosol generator and methods of making and using an aerosol generator 55 2003
* 2004/0050,383 Aerosol generator and methods of making and using an aerosol generator 8 2003
7367334 Fluid vaporizing device having controlled temperature profile heater/capillary tube 16 2003
* 2004/0182,389 Aerosol generator having heater in multilayered composite and method of use thereof 1 2003
* 2004/0170,405 Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate 5 2004
7373938 Disposable aerosol generator system and methods for administering the aerosol 34 2004
7163014 Disposable inhaler system 36 2004
 
Healthscan Products Inc. (1)
* 5297543 Medication inhaler mixer 37 1992
 
CHARLES RIVER LABORATORIES, INC. (1)
* 6725859 Apparatus for delivering air-borne substances 7 1998
 
GLAXO GROUP LIMITED (1)
* 5427089 Valved auxiliary device for use with aerosol container 68 1993
 
ASTRA AKTLEBOLAG (2)
6932962 Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides 29 1995
* 6524557 Aerosol formulations of peptides and proteins 41 1996
 
ACTIVAERO GMBH (1)
D697200 Mobile inhaler device 6 2011
 
MANNKIND CORPORATION (26)
7464706 Unit dose cartridge and dry powder inhaler 52 2003
* 2004/0182,387 Unit dose cartridge and dry powder inhaler 61 2003
* 2009/0241,949 DRY POWDER INHALATION SYSTEM 41 2009
9364619 Interactive apparatus and method for real-time profiling of inhalation efforts 1 2009
9061111 Unit dose capsules and dry powder inhaler 0 2012
8671937 Unit dose capsules and dry powder inhaler 22 2012
8950397 Unit dose cartridge and dry powder inhaler 0 2012
9364436 High capacity diketopiperazine microparticles and methods 0 2012
9339615 Dry powder inhaler and system for drug delivery 0 2013
9802012 Dry powder drug delivery system and methods 0 2013
9241903 Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent 0 2013
9511198 Dry powder inhaler and system for drug delivery 0 2013
9283193 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 0 2014
9630930 Diketopiperazine microparticles with defined specific surface areas 0 2014
9346766 Catalysis of diketopiperazine synthesis 0 2014
9700690 Inhalation apparatus 0 2014
9446133 Dry powder inhaler and system for drug delivery 0 2014
9220687 Substituted diketopiperazine analogs for use as drug delivery agents 1 2014
9801925 Potentiation of glucose elimination 0 2015
9706944 Apparatus and method for simulating inhalation efforts 0 2015
9446001 Increasing drug affinity for crystalline microparticle surfaces 0 2015
9655850 Substituted diketopiperazine analogs for use as drug delivery agents 0 2015
9675674 Diketopiperazine salts for drug delivery and related methods 0 2016
9717689 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 0 2016
9796688 Catalysis of diketopiperazine synthesis 0 2016
9662461 Dry powder drug delivery system and methods 0 2016
 
Fisons plc (1)
* 5239991 Disposable powder medicament inhalation device with peel-off cover 44 1992
 
BAXTER INTERNATIONAL INC. (3)
8672876 Fluid delivery system and flow control therefor 2 2008
8231566 Fluid delivery system and flow control therefor 1 2008
8226597 Fluid delivery system and flow control therefor 2 2008
 
AVADEL PHARMACEUTICALS (USA), INC. (1)
* 5318016 Inhalation device 22 1993
 
ARADIGM CORPORATION (62)
* 5450336 Method for correcting the drift offset of a transducer 70 1993
* 5394866 Automatic aerosol medication delivery system and methods 180 1993
* 5392768 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 152 1993
* 5709202 Intrapulmonary delivery of aerosolized formulations 123 1993
* 5497763 Disposable package for intrapulmonary delivery of aerosolized formulations 54 1993
* 5544646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 216 1994
* 5509404 Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values 223 1994
* 5672581 Method of administration of insulin 95 1994
* 5558085 Intrapulmonary delivery of peptide drugs 33 1994
* 5542410 Delivery of aeerosol medications for inspiration 79 1994
* 5622162 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 94 1995
* 5497764 Medication cassette for an automatic aerosol medication delivery 55 1995
* 5520166 Medication cassette for an automatic aerosol medication delivery system 164 1995
* 5718222 Disposable package for use in aerosolized delivery of drugs 120 1995
* 5724957 Intrapulmonary delivery of narcotics 193 1995
* 5608647 Method for releasing controlled amount of aerosol medication 203 1995
* 6098620 Device for aerosolizing narcotics 80 1995
* 5960792 Device for aerosolized delivery of peptide drugs 197 1995
* 5934272 Device and method of creating aerosolized mist of respiratory drug 279 1995
* 5915378 Creating an aerosolized formulation of insulin 150 1995
* 5655516 Delivery of aerosol medications for inspiration 68 1996
* 6012450 Intrapulmonary delivery of hematopoietic drug 153 1996
* 5823178 Disposable package for use in aerosolized delivery of drugs 99 1996
* 5743250 Insulin delivery enhanced by coached breathing 154 1996
* 5755218 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 173 1996
* 5743252 Method for releasing controlled amount of aerosol medication 81 1996
* 5888477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 69 1997
* 5819726 Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease 29 1997
* 5826570 Delivery of aerosol medications for inspiration 72 1997
* 5884620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 93 1997
* 6131567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 71 1998
* 6085753 Insulin delivery enhanced by coached breathing 38 1998
* 6123068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 75 1998
* 6098615 Method of reproducibly effecting a patient's glucose level 39 1998
* 5970973 Method of delivering insulin lispro 64 1998
* 5873358 Method of maintaining a diabetic patient's blood glucose level in a desired range 17 1998
* 6024090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 17 1998
* 5941240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 53 1998
* 6014969 Disposable package for use in aerosolized delivery of antibiotics 44 1998
6167880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 73 1999
6408854 Insulin delivery enhanced by coached breathing 35 2000
6250298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 41 2000
6551542 Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs 2 2000
6431166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 28 2001
* 2002/0124,852 Method of treating diabetes mellitus in a patient 4 2001
6427681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
6688304 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 13 2001
6431167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 9 2001
6647987 Insulin delivery enhanced by coached breathing 4 2002
7021309 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 4 2003
* 2004/0062,722 Method of use of monomeric insulin as a means for improving the reproducibilty of inhaled insulin 27 2003
7028686 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 40 2003
* 2004/0089,290 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 0 2003
7278419 Method for treating diabetes mellitus in a patient 29 2004
7448375 Method of treating diabetes mellitus in a patient 31 2005
* 2005/0274,377 Method of treating diabetes mellitus in a patient 5 2005
7490603 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 1 2005
* 2006/0093,556 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 59 2005
* 2006/0124,125 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 3 2006
* 2008/0099,011 INHALED INSULIN DOSAGE CONTROL DELIVERY ENHANCED BY CONTROLLING TOTAL INHALED VOLUME 7 2007
* 2008/0264,416 Method of Treating Diabetes Mellitus in a Patient 2 2008
* 2009/0241,950 METHOD OF TREATING DIABETES MELLITUS IN A PATIENT 0 2009
 
TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (1)
9233159 Methods and compositions for treating pain 0 2012
* Cited By Examiner