US Patent No: 4,926,852

Number of patents in Portfolio can not be more than 2000

Medication delivery system phase one

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An apparatus for use in inhaling pharmaceutical aerosols. The apparatus includes a mouthpiece and a rigid housing for receiving an aerosolized medicine. The rigid housing has one or more orifices which are spaced from the mouth piece so that flow through the housing is possible but is limited by the orifice(s) to a desired volumetric flow rate. The patient is aided by having the initial velocity of the aerosolized medicine reduced to zero by virtue of the initial delivery of the same to the housing interior, and by having the volumetric flow rate of the inhaled medication maintained below required limits thereby providing the conditions for optimal dosing. Further, the ability of the patient to inhale to total lung capacity with the flow through chamber enhances penetration of aerosolized drug to the lung periphery, and improves the ease of use for the patient.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
THE JOHNS HOPKINS UNIVERSITYBALTIMORE, MD1844

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adams, III George K Baltimore, MD 3 384
Laube, Beth L Baltimore, MD 4 486
Zoltan, Bart J Old Tappan, NJ 11 642

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Trudell Medical Limited (2)
4,534,343 Metered dose inhaler 127 1984
4,796,614 Collapsible inhalation valve 54 1987
 
HEALTH CARE CONCEPTS (1)
4,612,926 Dual-range aspirator device 12 1985
 
Key Pharmaceuticals, Inc. (1)
4,484,577 Drug delivery method and inhalation device therefor 152 1982
 
MAZDA MOTOR CORPORATION (1)
4,919,097 Engine output control system 21 1988

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
ARADIGM CORPORATION (53)
5,450,336 Method for correcting the drift offset of a transducer 66 1993
5,394,866 Automatic aerosol medication delivery system and methods 125 1993
5,392,768 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 116 1993
5,709,202 Intrapulmonary delivery of aerosolized formulations 89 1993
5,497,763 Disposable package for intrapulmonary delivery of aerosolized formulations 43 1993
5,544,646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 195 1994
5,509,404 Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values 173 1994
5,672,581 Method of administration of insulin 57 1994
5,558,085 Intrapulmonary delivery of peptide drugs 31 1994
5,542,410 Delivery of aeerosol medications for inspiration 62 1994
5,622,162 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 61 1995
5,497,764 Medication cassette for an automatic aerosol medication delivery 43 1995
5,520,166 Medication cassette for an automatic aerosol medication delivery system 135 1995
5,718,222 Disposable package for use in aerosolized delivery of drugs 104 1995
5,724,957 Intrapulmonary delivery of narcotics 150 1995
5,608,647 Method for releasing controlled amount of aerosol medication 154 1995
6,098,620 Device for aerosolizing narcotics 72 1995
5,960,792 Device for aerosolized delivery of peptide drugs 175 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 191 1995
5,915,378 Creating an aerosolized formulation of insulin 135 1995
5,655,516 Delivery of aerosol medications for inspiration 29 1996
6,012,450 Intrapulmonary delivery of hematopoietic drug 131 1996
5,823,178 Disposable package for use in aerosolized delivery of drugs 77 1996
5,743,250 Insulin delivery enhanced by coached breathing 120 1996
5,755,218 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 118 1996
5,743,252 Method for releasing controlled amount of aerosol medication 61 1996
5,888,477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 31 1997
5,819,726 Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease 25 1997
5,826,570 Delivery of aerosol medications for inspiration 45 1997
5,884,620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 49 1997
6,131,567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 43 1998
6,085,753 Insulin delivery enhanced by coached breathing 37 1998
6,123,068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 50 1998
6,098,615 Method of reproducibly effecting a patient's glucose level 37 1998
5,970,973 Method of delivering insulin lispro 50 1998
5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range 16 1998
6,024,090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 16 1998
5,941,240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 44 1998
6,014,969 Disposable package for use in aerosolized delivery of antibiotics 33 1998
6,167,880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 62 1999
6,408,854 Insulin delivery enhanced by coached breathing 24 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 38 2000
6,551,542 Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs 1 2000
6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 20 2001
6,427,681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
6,688,304 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 11 2001
6,431,167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 6 2001
6,647,987 Insulin delivery enhanced by coached breathing 3 2002
7,021,309 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 3 2003
7,028,686 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 12 2003
7,278,419 Method for treating diabetes mellitus in a patient 3 2004
7,448,375 Method of treating diabetes mellitus in a patient 4 2005
7,490,603 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 1 2005
 
NOVARTIS PHARMA AG (23)
5,458,135 Method and device for delivering aerosolized medicaments 215 1992
5,775,320 Method and device for delivering aerosolized medicaments 108 1995
5,780,014 Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin 53 1996
6,051,256 Dispersible macromolecule compositions and methods for their preparation and use 86 1996
6,685,967 Methods and compositions for pulmonary delivery of insulin 26 1996
5,997,848 Methods and compositions for pulmonary delivery of insulin 119 1997
6,138,668 Method and device for delivering aerosolized medicaments 61 1997
5,993,783 Method and apparatus for pulmonary administration of dry powder .alpha.1-antitrypsin 46 1998
6,655,379 Aerosolized active agent delivery 35 1999
6,509,006 Devices compositions and methods for the pulmonary delivery of aerosolized medicaments 24 1999
6,423,344 Dispersible macromolecule compositions and methods for their preparation and use 49 2000
6,681,767 Method and device for delivering aerosolized medicaments 26 2000
6,606,992 Systems and methods for aerosolizing pharmaceutical formulations 32 2000
6,543,448 Apparatus and methods for dispersing dry powder medicaments 45 2000
6,546,929 Dry powder dispersing apparatus and methods for their use 16 2001
6,592,904 Dispersible macromolecule compositions and methods for their preparation and use 37 2001
6,797,258 Compositions and methods for the pulmonary delivery of aerosolized macromolecules 19 2002
6,737,045 Methods and compositions for the pulmonary delivery insulin 22 2002
6,901,929 Dry powder dispersing apparatus and methods for their use 6 2002
6,921,527 Composition for pulmonary administration comprising a drug and a hydrophobic amino acid 28 2003
7,185,651 Flow regulator for aerosol drug delivery and methods 3 2003
7,422,013 Dry powder dispersing apparatus and methods for their use 5 2005
8,173,168 Dispersible macromolecule compositions and methods for their preparation and use 0 2006
 
PHILIP MORRIS USA INC. (19)
6,557,552 Aerosol generator and methods of making and using an aerosol generator 39 2000
6,701,921 Aerosol generator having heater in multilayered composite and method of use thereof 24 2000
6,681,998 Aerosol generator having inductive heater and method of use thereof 21 2000
6,501,052 Aerosol generator having multiple heating zones and methods of use thereof 39 2000
6,491,233 Vapor driven aerosol generator and method of use thereof 34 2000
6,640,050 Fluid vaporizing device having controlled temperature profile heater/capillary tube 19 2001
6,568,390 Dual capillary fluid vaporizing device 47 2001
6,883,516 Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution 21 2001
6,804,458 Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate 11 2001
6,681,769 Aerosol generator having a multiple path heater arrangement and method of use thereof 19 2001
7,077,130 Disposable inhaler system 14 2001
6,701,922 Mouthpiece entrainment airflow control for aerosol generators 99 2001
7,173,222 Aerosol generator having temperature controlled heating zone and method of use thereof 8 2002
7,128,067 Method and apparatus for generating an aerosol 10 2003
6,715,487 Dual capillary fluid vaporizing device 29 2003
7,117,867 Aerosol generator and methods of making and using an aerosol generator 9 2003
7,367,334 Fluid vaporizing device having controlled temperature profile heater/capillary tube 5 2003
7,373,938 Disposable aerosol generator system and methods for administering the aerosol 4 2004
7,163,014 Disposable inhaler system 9 2004
 
NOVARTIS AG (6)
8,408,200 Flow resistance modulated aerosolized active agent delivery 1 1999
7,097,827 Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments 6 2002
7,138,141 Dispersible macromolecule compositions and methods for their preparation and use 7 2003
7,521,069 Methods and compositions for pulmonary delivery of insulin 11 2003
8,161,969 Dry powder dispersing apparatus and methods for their use 0 2008
8,337,895 Spray drying process control of drying kinetics 0 2009
 
MPEX PHARMACEUTICALS, INC. (5)
8,629,139 Topical use of Levofloxacin for reducing lung inflammation 0 2009
8,546,423 Aerosolized fluoroquinolones and uses thereof 0 2009
8,524,734 Aerosolized fluoroquinolones and uses thereof 0 2009
8,524,735 Aerosolized fluoroquinolones and uses thereof 0 2009
8,357,696 Aerosolized fluoroquinolones and uses thereof 0 2010
 
ASTRAZENECA AB (4)
6,794,357 Compositions for inhalation 11 1996
6,632,456 Compositions for inhalation 4 1997
6,846,801 Systemic administration of a therapeutic preparation 1 1998
6,610,653 Therapeutic preparation for inhalation 2 2000
 
BAXTER INTERNATIONAL INC. (3)
8,672,876 Fluid delivery system and flow control therefor 0 2008
8,231,566 Fluid delivery system and flow control therefor 0 2008
8,226,597 Fluid delivery system and flow control therefor 0 2008
 
KOS LIFE SCIENCES, INC. (3)
6,418,925 Low spray force, low retention atomization system 16 2000
6,595,204 Spacer for an inhaler 0 2001
6,567,686 Method for improving lung delivery of pharmaceutical aerosols 3 2001
 
QUADRANT DRUG DELIVERY LIMITED (3)
7,785,631 Solid dose delivery vehicle and methods of making same 0 2005
7,780,991 Solid dose delivery vehicle and methods of making same 1 2005
7,744,925 Solid dose delivery vehicle and methods of making same 1 2005
 
SP MEDICAL LLC (3)
6,453,900 Inhaler device 3 2000
6,523,536 Dual-canister inhaler having a spacer and easy to operate lever mechanism 25 2001
6,698,422 Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece 14 2002
 
ASTRA AKTLEBOLAG (2)
6,932,962 Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides 15 1995
6,524,557 Aerosol formulations of peptides and proteins 18 1996
 
MANNKIND CORPORATION (2)
7,464,706 Unit dose cartridge and dry powder inhaler 12 2003
8,671,937 Unit dose capsules and dry powder inhaler 0 2012
 
Pediatric Innovations USA, LLC (2)
D701956 Nasal device 0 2013
D701599 Nasal device 0 2013
 
SCIOS INC. (2)
6,475,796 Vascular endothelial growth factor variants 9 2000
6,887,848 Vascular endothelial growth factor variants 2 2002
 
3M INNOVATIVE PROPERTIES COMPANY (1)
6,615,826 Slow spray metered dose inhaler 13 2000
 
ACTIVAERO GMBH (1)
D697200 Mobile inhaler device 0 2011
 
BECTON, DICKINSON AND COMPANY (1)
8,413,651 Disposable spacer for inhalation delivery of aerosolized drugs and vaccines 0 2008
 
CHARLES RIVER LABORATORIES, INC. (1)
6,725,859 Apparatus for delivering air-borne substances 3 1998
 
DEX MEDIA, INC. (1)
6,516,796 Aerosol generator and methods of making and using an aerosol generator 52 2000
 
FISONS PLC (1)
5,239,991 Disposable powder medicament inhalation device with peel-off cover 41 1992
 
FSC LABORATORIES, INC. (1)
5,318,016 Inhalation device 14 1993
 
GLAXO GROUP LIMITED (1)
5,427,089 Valved auxiliary device for use with aerosol container 50 1993
 
Healthscan Products Inc. (1)
5,297,543 Medication inhaler mixer 21 1992
 
MEF MEDICINE, INC. (1)
D618335 Nasal device 4 2009
 
MIRIS MEDICAL INCORPORATED, A CORP. OF CA (1)
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NEKTAR THERAPEUTICS (1)
8,273,330 Particulate materials 0 2003
 
PROFILE DRUG DELIVERY LIMITED (1)
6,779,521 Combination mouthpiece for inhalation therapy devices used by oxygen dependent patients 0 2002
 
Thayer Medical Corporation (1)
D362500 Medication inhaler spacer 13 1994
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
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VENTAIRA PHARMACEUTICALS, INC. (1)
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Other [Check patent profile for assignment information] (4)
5,178,138 Drug delivery device 186 1990
5,752,502 General purpose aerosol inhalation apparatus 55 1993
5,477,849 Spacer for medication inhaler 23 1994
5,809,996 Collapsible metered dose inhaler 18 1996