US Patent No: 4,927,516

Number of patents in Portfolio can not be more than 2000

Enzyme sensor

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ATTORNEY / AGENT: (SPONSORED)
 

Importance

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Abstract

Disclosed is an enzyme sensor for measuring a predetermined substrate concentration by potentiometric or amperometric response on the basis of an enzyme. In one aspect, a solid-state enzyme sensor measures a predetermined substrate concentration by potentiometric response and includes a solid enzyme membrane-coated electrically conductive base, redox layer or ion-sensitive layer. In another aspect, a solid-state enzyme sensor measures a predetermined substrate concentration by amperometric response and includes a solid enzyme membrane-coated oxygen reduction catalyst layer. Also disclosed is an enzyme control layer for controlling the outflow and inflow of the enzyme layer.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
TERUMO KABUSHIKI KAISHATOKYO1152

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Oyama, Noboru Musashino, JP 30 958
Shimomura, Takeshi Machida, JP 55 1253
Uchida, Naoto Ageo, JP 25 513
Yamaguchi, Shuichiro Miyazaki-gun, JP 44 1088

Cited Art

Patent Info (Count) # Cites Year
 
CASE WESTERN RESERVE UNIVERSITY (1)
4,655,880 Apparatus and method for sensing species, substances and substrates using oxidase 316 1983
 
CHILDREN'S HOSPITAL MEDICAL CENTER (1)
4,680,268 Implantable gas-containing biosensor and method for measuring an analyte such as glucose 300 1985
 
GTE LABORATORIES INCORPORATED (1)
4,704,193 Covalently coupled cofactor modified electrodes and methods of synthesis and use 39 1986
 
MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (1)
4,376,689 Coenzyme immobilized electrode 25 1981
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4,671,288 Electrochemical cell sensor for continuous short-term use in tissues and blood 445 1985
 
UNIVERSITY OF PITTSBURGH (1)
4,340,448 Potentiometric detection of hydrogen peroxide and apparatus therefor 23 1978

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ABBOTT DIABETES CARE INC. (94)
6,338,790 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 345 1999
6,299,757 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 340 1999
6,461,496 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 471 1999
6,616,819 Small volume in vitro analyte sensor and methods 324 1999
6,551,494 Small volume in vitro analyte sensor 297 2000
6,592,745 Method of using a small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 275 2000
6,618,934 Method of manufacturing small volume in vitro analyte sensor 415 2000
6,654,625 Mass transport limited in vivo analyte sensor 313 2000
6,591,125 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 422 2000
6,329,161 Subcutaneous glucose electrode 451 2000
6,942,518 Small volume in vitro analyte sensor and methods 218 2001
6,749,740 Small volume in vitro analyte sensor and methods 199 2001
7,003,340 Electrochemical analyte sensor 175 2002
7,058,437 Methods of determining concentration of glucose 186 2003
7,550,069 Small volume in vitro analyte sensor 2 2003
7,225,535 Method of manufacturing electrochemical sensors 180 2003
7,563,350 Small volume in vitro analyte sensor 4 2003
7,381,184 Sensor inserter assembly 40 2003
6,975,893 Mass transport limited in vivo analyte sensor 100 2003
7,811,231 Continuous glucose monitoring system and methods of use 14 2003
8,066,639 Glucose measuring device for use in personal area network 0 2004
8,112,240 Method and apparatus for providing leak detection in data monitoring and management systems 0 2005
7,976,778 Blood glucose tracking apparatus 2 2005
7,462,264 Subcutaneous glucose electrode 1 2005
7,721,412 Method of making an electrochemical sensor 6 2005
7,766,829 Method and system for providing basal profile modification in analyte monitoring and management systems 3 2005
8,226,891 Analyte monitoring devices and methods therefor 1 2006
7,620,438 Method and system for powering an electronic device 0 2006
8,333,714 Method and system for providing an integrated analyte sensor insertion device and data processing unit 0 2006
8,123,686 Method and apparatus for providing rolling data in communication systems 0 2007
8,186,044 Method of manufacturing small volume in vitro analyte sensors 0 2007
8,231,532 Analyte monitoring device and methods of use 0 2007
7,920,907 Analyte monitoring system and method 3 2007
8,105,476 Integrated lancing and measurement device 1 2007
8,029,442 Sensor inserter assembly 0 2007
7,582,059 Sensor inserter methods of use 1 2007
8,273,227 Sensor for in vitro determination of glucose 0 2007
8,168,051 Sensor for determination of glucose 0 2007
8,136,220 Method of making an electrochemical sensor 0 2007
8,117,734 Method of making an electrochemical sensor 0 2007
7,879,213 Sensor for in vitro determination of glucose 1 2007
7,861,397 Method of making an electrochemical sensor 0 2007
8,091,220 Methods of making small volume in vitro analyte sensors 0 2007
8,066,858 Analyte sensor with insertion monitor, and methods 0 2007
7,988,845 Integrated lancing and measurement device and analyte measuring methods 0 2008
8,114,270 Small volume in vitro analyte sensor 0 2008
7,909,984 Small volume in vitro analyte sensor 0 2008
7,928,850 Analyte monitoring system and methods 11 2008
8,142,642 Small volume in vitro analyte sensor 0 2008
7,906,009 Small volume in vitro analyte sensor 0 2008
8,414,749 Subcutaneous glucose electrode 0 2008
8,103,456 Method and device for early signal attenuation detection using blood glucose measurements 2 2009
8,255,031 Analyte monitoring device and methods of use 0 2009
8,226,555 Analyte monitoring device and methods of use 0 2009
8,162,829 Analyte monitoring device and methods of use 0 2009
8,162,830 Analyte monitoring device and methods of use 0 2009
8,346,337 Analyte monitoring device and methods of use 0 2009
8,149,117 Analyte monitoring system and methods 0 2009
8,425,758 Small volume in vitro analyte sensor and methods of making 0 2009
8,377,378 Small volume in vitro analyte sensor and methods of making 0 2009
8,372,261 Small volume in vitro analyte sensor and methods of making 0 2009
8,272,125 Method of manufacturing in vitro analyte sensors 0 2009
8,273,241 Small volume in vitro analyte sensor and methods of making 0 2009
8,268,144 Small volume in vitro analyte sensor and methods of making 0 2009
8,268,163 Small volume in vitro analyte sensor and methods of making 0 2009
8,262,996 Small volume in vitro sensor and methods of making 0 2009
8,226,815 Small volume in vitro sensor and methods of making 0 2009
8,221,685 Small volume in vitro sensor and methods of making 0 2009
8,211,363 Small volume in vitro analyte sensor and methods of making 0 2009
8,192,611 Small volume in vitro analyte sensor and methods of making 0 2009
8,187,895 Small volume in vitro analyte sensor and methods of making 0 2009
8,182,670 Small volume in vitro analyte sensor and methods of making 0 2009
8,182,671 Small volume in vitro analyte sensor and methods of making 0 2009
8,163,164 Small volume in vitro analyte sensor and methods of making 1 2009
8,153,063 Small volume in vitro analyte sensor and methods of making 0 2009
8,142,643 Small volume in vitro analyte sensor 0 2009
8,123,929 Small volume in vitro analyte sensor 0 2009
8,118,992 Small volume in vitro analyte sensor 0 2009
8,118,993 Small volume in vitro analyte sensor and methods of making 0 2009
8,114,271 Small volume in vitro analyte sensor 0 2009
8,087,162 Methods of making small volume in vitro analyte sensors 0 2009
8,083,924 Small volume in vitro analyte sensor and methods of making 0 2009
8,083,928 Small volume in vitro analyte sensor and methods of making 1 2009
8,083,929 Small volume in vitro sensor and methods of making 1 2009
8,175,673 Analyte monitoring device and methods of use 0 2009
8,235,896 Analyte monitoring device and methods of use 0 2009
8,177,716 Analyte monitoring device and methods of use 0 2009
8,268,243 Blood glucose tracking apparatus and methods 0 2009
8,226,557 Analyte monitoring device and methods of use 0 2009
8,236,242 Blood glucose tracking apparatus and methods 0 2010
8,425,743 Small volume in vitro analyte sensor and methods of making 0 2010
8,287,454 Analyte monitoring device and methods of use 0 2010
8,187,183 Continuous glucose monitoring system and methods of use 0 2010
8,362,904 Analyte monitoring system and methods 0 2011
 
DEXCOM, INC. (87)
8,060,173 System and methods for processing analyte sensor data 0 2003
7,778,680 System and methods for processing analyte sensor data 48 2003
8,010,174 Systems and methods for replacing signal artifacts in a glucose sensor data stream 26 2003
7,591,801 Integrated delivery device for continuous glucose sensor 181 2004
7,657,297 Implantable analyte sensor 115 2004
7,519,408 Integrated receiver for continuous analyte sensor 192 2004
7,715,893 Calibration techniques for a continuous analyte sensor 98 2004
8,282,549 Signal processing for continuous analyte sensor 0 2004
7,637,868 Composite material for implantable device 113 2005
7,826,981 System and methods for processing analyte sensor data 46 2005
8,170,803 Transcutaneous analyte sensor 0 2005
7,885,697 Transcutaneous analyte sensor 28 2005
7,783,333 Transcutaneous medical device with variable stiffness 38 2005
7,905,833 Transcutaneous analyte sensor 21 2005
7,530,950 Transcutaneous analyte sensor 0 2005
7,899,511 Low oxygen in vivo analyte sensor 35 2006
7,857,760 Analyte sensor 33 2006
7,640,048 Analyte sensor 148 2006
7,920,906 System and methods for processing analyte sensor data for sensor calibration 11 2006
8,231,531 Analyte sensor 1 2006
8,233,959 Systems and methods for processing analyte sensor data 4 2006
8,275,437 Transcutaneous analyte sensor 0 2007
8,160,669 Transcutaneous analyte sensor 10 2007
8,260,393 Systems and methods for replacing signal data artifacts in a glucose sensor data stream 3 2007
8,394,021 System and methods for processing analyte sensor data 0 2007
8,396,528 Analyte sensor 0 2008
7,949,381 Transcutaneous analyte sensor 4 2008
7,797,028 System and methods for processing analyte sensor data 34 2008
7,599,726 System and methods for processing analyte sensor data 172 2008
7,583,990 System and methods for processing analyte sensor data 172 2008
7,901,354 Low oxygen in vivo analyte sensor 26 2008
7,771,352 Low oxygen in vivo analyte sensor 46 2008
8,282,550 Integrated receiver for continuous analyte sensor 0 2008
7,927,274 Integrated receiver for continuous analyte sensor 17 2008
8,052,601 System and methods for processing analyte sensor data 2 2008
8,374,667 Signal processing for continuous analyte sensor 0 2008
8,257,259 Signal processing for continuous analyte sensor 1 2008
8,423,113 Systems and methods for processing sensor data 0 2008
8,417,312 Systems and methods for processing sensor data 0 2008
8,369,919 Systems and methods for processing sensor data 1 2008
8,290,559 Systems and methods for processing sensor data 0 2008
7,896,809 Dual electrode system for a continuous analyte sensor 33 2008
8,287,453 Analyte sensor 2 2008
8,290,560 Transcutaneous analyte sensor 0 2008
7,935,057 Systems and methods for replacing signal artifacts in a glucose sensor data stream 0 2009
8,229,535 Systems and methods for blood glucose monitoring and alert delivery 0 2009
8,280,475 Transcutaneous analyte sensor 0 2009
8,251,906 Signal processing for continuous analyte sensor 1 2009
7,976,492 Integrated delivery device for continuous glucose sensor 3 2009
8,290,561 Signal processing for continuous analyte sensor 0 2009
8,216,139 Signal processing for continuous analyte sensor 2 2009
8,265,725 Signal processing for continuous analyte sensor 1 2009
8,233,958 Signal processing for continuous analyte sensor 2 2009
8,150,488 Systems and methods for replacing signal artifacts in a glucose sensor data stream 5 2009
8,128,562 Systems and methods for replacing signal artifacts in a glucose sensor data stream 5 2009
8,073,519 Systems and methods for replacing signal artifacts in a glucose sensor data stream 6 2009
8,005,525 Systems and methods for replacing signal artifacts in a glucose sensor data stream 22 2009
7,998,071 Systems and methods for replacing signal artifacts in a glucose sensor data stream 2 2009
7,917,186 Calibration techniques for a continuous analyte sensor 9 2009
8,206,297 System and methods for processing analyte sensor data 4 2009
8,332,008 System and methods for processing analyte sensor data 2 2010
8,285,354 System and methods for processing analyte sensor data 0 2010
7,986,986 System and methods for processing analyte sensor data 28 2010
7,959,569 System and methods for processing analyte sensor data 28 2010
7,955,261 System and methods for processing analyte sensor data 28 2010
7,933,639 System and methods for processing analyte sensor data 28 2010
7,925,321 System and methods for processing analyte sensor data 26 2010
8,005,524 Signal processing for continuous analyte sensor 21 2010
8,167,801 Systems and methods for replacing signal artifacts in a glucose sensor data stream 1 2010
8,428,679 System and methods for processing analyte sensor data 0 2010
8,290,562 System and methods for processing analyte sensor data 2 2010
7,914,450 System and methods for processing analyte sensor data 40 2010
8,073,520 Systems and methods for replacing signal artifacts in a glucose sensor data stream 6 2010
7,979,104 System and methods for processing analyte sensor data 28 2010
8,229,536 Systems and methods for replacing signal artifacts in a glucose sensor data stream 4 2010
8,000,901 Transcutaneous analyte sensor 15 2010
8,249,684 Calibration techniques for a continuous analyte sensor 2 2010
8,160,671 Calibration techniques for a continuous analyte sensor 4 2010
8,435,179 Systems and methods for replacing signal artifacts in a glucose sensor data stream 0 2011
8,346,338 System and methods for replacing signal artifacts in a glucose sensor data stream 1 2011
8,292,810 Systems and methods for replacing signal artifacts in a glucose sensor data stream 3 2011
8,412,301 Systems and methods for replacing signal artifacts in a glucose sensor data stream 0 2011
8,195,265 Systems and methods for replacing signal artifacts in a glucose sensor data stream 4 2011
8,311,749 Transcutaneous analyte sensor 0 2011
8,321,149 Transcutaneous analyte sensor 2011
8,386,004 Calibration techniques for a continuous analyte sensor 0 2011
8,428,678 Calibration techniques for a continuous analyte sensor 0 2012
 
ROCHE OPERATIONS LTD. (26)
RE36268 Method and apparatus for amperometric diagnostic analysis 119 1996
7,597,793 System and method for analyte measurement employing maximum dosing time delay 2 2003
7,494,816 System and method for determining a temperature during analyte measurement 1 2003
7,488,601 System and method for determining an abused sensor during analyte measurement 6 2003
7,452,457 System and method for analyte measurement using dose sufficiency electrodes 3 2003
7,390,667 System and method for analyte measurement using AC phase angle measurements 5 2003
8,071,030 Test strip with flared sample receiving chamber 0 2004
7,829,023 Test strip with vent opening 4 2004
7,749,437 Method and reagent for producing narrow, homogenous reagent stripes 1 2004
7,727,467 Reagent stripe for test strip 5 2004
7,645,373 System and method for coding information on a biosensor test strip 1 2004
7,645,421 System and method for coding information on a biosensor test strip 3 2004
7,604,721 System and method for coding information on a biosensor test strip 6 2004
7,569,126 System and method for quality assurance of a biosensor test strip 5 2004
7,556,723 Electrode design for biosensor 2 2005
7,338,639 System and method for analyte measurement 73 2006
8,287,703 Biosensor and method of making 0 2008
7,977,112 System and method for determining an abused sensor during analyte measurement 0 2008
7,879,618 Method and reagent for producing narrow, homogenous reagent strips 0 2009
7,892,849 Reagent stripe for test strip 3 2009
8,092,668 System and method for quality assurance of a biosensor test strip 0 2009
8,083,993 System and method for coding information on a biosensor test strip 0 2009
8,119,414 Test strip with slot vent opening 0 2010
8,142,721 Test strip with slot vent opening 0 2010
8,211,379 Test strip with slot vent opening 0 2011
8,222,044 Test strip with flared sample receiving chamber 0 2011
 
E. HELLER & COMPANY (23)
6,134,461 Electrochemical analyte 541 1998
6,175,752 Analyte monitoring device and methods of use 668 1998
6,484,046 Electrochemical analyte sensor 412 2000
6,565,509 Analyte monitoring device and methods of use 450 2000
7,996,054 Electrochemical analyte sensor 0 2006
8,409,131 Analyte monitoring device and methods of use 0 2007
7,860,544 Analyte monitoring device and methods of use 4 2007
8,260,392 Analyte monitoring device and methods of use 0 2008
8,224,413 Analyte monitoring device and methods of use 0 2008
8,273,022 Analyte monitoring device and methods of use 0 2009
8,391,945 Analyte monitoring device and methods of use 0 2009
8,346,336 Analyte monitoring device and methods of use 0 2009
8,366,614 Analyte monitoring device and methods of use 0 2009
8,380,273 Analyte monitoring device and methods of use 0 2009
8,306,598 Analyte monitoring device and methods of use 0 2009
8,275,439 Analyte monitoring device and methods of use 0 2009
8,265,726 Analyte monitoring device and methods of use 0 2009
8,372,005 Analyte monitoring device and methods of use 0 2009
8,357,091 Analyte monitoring device and methods of use 0 2009
8,353,829 Analyte monitoring device and methods of use 0 2009
7,885,699 Analyte monitoring device and methods of use 3 2010
7,869,853 Analyte monitoring device and methods of use 3 2010
8,226,558 Analyte monitoring device and methods of use 0 2010
 
ROCHE DIAGNOSTICS OPERATIONS, INC. (15)
5,128,015 Method and apparatus for amperometric diagnostic analysis 231 1989
5,872,713 Synchronized analyte testing system 208 1997
6,106,780 Synchronized analyte testing system 92 1999
6,544,475 Synchronized analyte testing system 24 2000
7,018,843 Instrument 29 2001
7,407,811 System and method for analyte measurement using AC excitation 7 2003
8,206,565 System and method for coding information on a biosensor test strip 0 2004
8,058,077 Method for coding information on a biosensor test strip 0 2004
7,718,439 System and method for coding information on a biosensor test strip 7 2004
7,927,882 Instrument 0 2005
7,923,258 Instrument 1 2008
8,071,384 Control and calibration solutions and methods for their use 0 2008
8,148,164 System and method for determining the concentration of an analyte in a sample fluid 0 2009
8,293,538 System and method for coding information on a biosensor test strip 0 2010
8,298,828 System and method for determining the concentration of an analyte in a sample fluid 0 2012
 
THERASENSE, INC. (8)
5,262,305 Interferant eliminating biosensors 333 1991
5,320,725 Electrode and method for the detection of hydrogen peroxide 304 1992
5,356,786 Interferant eliminating biosensor 409 1993
6,103,033 Process for producing an electrochemical biosensor 528 1998
6,162,611 Subcutaneous glucose electrode 442 2000
6,514,718 Subcutaneous glucose electrode 308 2001
6,881,551 Subcutaneous glucose electrode 272 2003
6,973,706 Method of making a transcutaneous electrochemical sensor 143 2003
 
I-STAT CORPORATION (4)
5,200,051 Wholly microfabricated biosensors and process for the manufacture and use thereof 508 1989
5,466,575 Process for the manufacture of wholly microfabricated biosensors 85 1992
5,837,446 Process for the manufacture of wholly microfabricated biosensors 16 1995
6,306,594 Methods for microdispensing patterened layers 50 1998
 
TERUMO KABUSHIKI KAISHA (4)
5,066,383 Reference electrode, ion sensor and method of manufacturing the same 8 1989
5,186,808 Film-coated sensor 8 1990
5,190,636 Ion-sensitive film, method of producing the same and ion sensor 1 1990
5,213,675 Reference electrode, ion sensor and method of manufacturing the same 4 1991
 
ABBOTT POINT OF CARE INC. (3)
7,540,948 Blood urea nitrogen (BUN) sensor 3 2005
8,236,517 Blood urea nitrogen (BUN) sensor 0 2009
8,182,663 Blood urea nitrogen (BUN) sensor 0 2009
 
APPLIED BIOMEDICAL, LLC (3)
6,576,102 Electrochemical sensor and method thereof 10 2001
6,572,745 Electrochemical sensor and method thereof 15 2001
6,849,216 Method of making sensor 92 2003
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (3)
5,264,104 Enzyme electrodes 387 1992
5,264,105 Enzyme electrodes 297 1993
6,284,478 Subcutaneous glucose electrode 371 1996
 
E. HELLER & COMPANY, INC. (3)
6,143,164 Small volume in vitro analyte sensor 474 1998
6,120,676 Method of using a small volume in vitro analyte sensor 535 1999
6,576,101 Small volume in vitro analyte sensor 298 1999
 
MEDTRONIC MINIMED, INC. (3)
D433755 Glucose sensor 5 1999
D452323 Glucose sensor 9 2000
D469540 Glucose sensor 7 2001
 
YSI INCORPORATED (3)
5,932,799 Microfluidic analyzer module 174 1997
6,073,482 Fluid flow module 50 1999
6,293,012 Method of making a fluid flow module 13 2000
 
BAYER HEALTHCARE LLC (2)
8,425,757 Gated amperometry 0 2007
8,404,100 Gated voltammetry 0 2008
 
MILES INC. (2)
5,202,261 Conductive sensors and their use in diagnostic assays 221 1991
5,250,439 Use of conductive sensors in diagnostic assays 239 1992
 
BOEHRINGER MANNHEIM GMBH (1)
5,122,244 Method and sensor electrode system for the electrochemical determination of an analyte or an oxidoreductase as well as the use of suitable compounds therefor 157 1991
 
CHUNG YUAN CHRISTIAN UNIVERSITY (1)
7,794,778 Amperometric sensor for uric acid and method for the same 0 2005
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (4)
5,205,920 Enzyme sensor and method of manufacturing the same 227 1990
5,830,341 Electrodes and metallo isoindole ringed compounds 115 1996
5,795,453 Electrodes and metallo isoindole ringed compounds 57 1996
8,442,610 System and methods for processing analyte sensor data 0 2008