Relaxation of smooth vascular muscle
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United States of America Patent
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May 22, 1990
Grant Date -
N/A
app pub date -
Dec 17, 1987
filing date -
Dec 17, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Certain substances are provided which have the ability to relax smooth vascular muscle, having an endothelial lining, when administered in vitro or by intravenous injection. Examples of useful substances which are pharmaceutically-acceptable include phospholipase A.sub.2 (PLA.sub.2) and certain lysolecithins. The concentration required is at least about 3 units of PLA.sub.2 and at least about 10.sup.-5 Molar lysolecithin. The lysolecithins are dissolved in a suitable solvent, such as dimethyl sulfoxide, for injection. Alternatively, phospholipase A.sub.2 is administered directly. The resulting solutions should have a pharmacologically-effective amount of the substance dissolved therein. Importantly, the body does not develop a tolerance to the lysolecithin.
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