Antitumor protein gene of streptococcus pyogenes Su, plasmids containing the gene, transformant cells harboring the plasmids, and process for producing the antitumor protein
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United States of America Patent
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May 29, 1990
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N/A
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Dec 24, 1986
filing date -
Dec 28, 1985
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Expired
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Abstract
Amino acid sequence of N-terminal region of streptococcal acid glycoprotein (SAGP), and antitumor glycoprotein produced by Streptococcus pyogenes Su, was determined, and DNA probes which are complementary to SAGP gene were synthesized. Chromosomal DNA fragment of S.pyogenes Su, which hybridized with those probes was cloned into E.coli, and a restriction map of plasmid DNA harboring SAGP gene was revealed and upon it, DNA sequence or amino acid sequence of SAGP gene was determined.
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