Heterogeneous interpenetrating polymer networks for the controlled release of drugs

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United States of America Patent

PATENT NO 4931287
SERIAL NO

07206593

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Abstract

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A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N'-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styrene, an alkyl methacrylate, or polytetramethylene ether glycol. The relative amounts of the two components, or 'domains', can be varied, as can the diffusivities and solubilities of the drug combinations to be loaded therein, to control and change as desired the timed release profile of incorporated drug. Prolonged pseudo-zero order release can be obtained where one domain acts as a diffusion barrier layer to the release of drug from the other domain.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF UTAH RESEARCH FOUNDATION615 ARAPEEN DRIVE SUITE 310 SALT LAKE CITY UT 84108

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bae, You H Salt Lake City, UT 5 518
Kim, Sung W Salt Lake City, UT 7 455
Okano, Teruo Urayasu, JP 109 1658

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