Platinum-polymer complexes and their use as antitumor agents

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United States of America Patent

PATENT NO 4931553
SERIAL NO

07192451

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Platinum(amine) complexes, when covalently linked to a water-soluble, biodegradable or biostable polymer, exhibit high antitumor activity at low dosages of platinum against L1210 and solid tumors. The complexes are platinum square planar complexes and octahedral structures of the formulae ##STR1## wherein A.sub.2 represents either 2 ammonia ligands, 2 monodentate amine ligands or a single bidentate amine ligand; P is either a biodegradable or a biostable but biocompatible polymer having pendent anionic groups which form covalent linkages with Pt; o is a positive integer and X is an anionic ligand.

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Patent Owner(s)

Patent OwnerAddress
ANDRULIS PHARMACEUTICALS CORPORATION179 REHOBOTH AVENUE UNIT 1378 REHOBOTH DE 19971

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Andrulis, Jr Peter J 7315 Wisconsin Ave., Bethesda, MD 20814 9 438
Gill, Devinder S 11,800 Baltimore Ave., Beltsville, MD 20705 5 111

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