2-(acylthio)methyl dihydropyridines, and pharmaceutical compositions containing them
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United States of America Patent
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Jun 19, 1990
Grant Date -
N/A
app pub date -
Jul 28, 1987
filing date -
Jul 29, 1986
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Compounds of formula I wherein R.sub.1 is an alkoxy carbonyl, aminocarbonyl, acetyl, benzyl, cyano or nitro group; R.sub.2 is as optionally substituted phenyl, aryl, hetaryl residue; R.sub.3 is an alkoxy-carbonyl group, X is an oxygen or sulphur atom, R.sub.4 is hydrogen, an optionally substituted alkyl, cycloalkyl, alkenyl group, Y is a single bond oxygen, sulphur or substituted nitrogen atom. Compounds of formula I are prepared by acylation from a 2-mercaptomethyl-1,4-dihydropyridine and are useful in therapy.
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