Production of 2,3'-anhydro-2'-deoxyuridine derivatives
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United States of America Patent
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Jun 26, 1990
Grant Date -
N/A
app pub date -
Nov 8, 1988
filing date -
Nov 13, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A process for the production of a 5-substituted derivative of a 2,3'-anhydro-2'-deoxyuridine preferably corresponding to the following general formula: ##STR1## wherein R.sup.1 represents H, alkyl, aryl, halogeno or CF.sub.3 ; characterized in that it comprises heating a 5-substituted derivative of a 2'-deoxyuridine preferably corresponding to the following general formula: ##STR2## wherein R.sup.1 is as defined above; in the presence of a sulphite transfer reagent and preferably a solvent is disclosed. This process improves the production of valuable intermediates and hence facilitates and reduces the cost of production of pharmacologically-interesting compounds.
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