Fecal occult blood test methods
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United States of America Patent
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-
Jul 3, 1990
Issued Date -
N/A
app pub date -
Dec 24, 1987
filing date -
Jun 2, 1986
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An improved method for detecting peroxidatively active materials in a sample is provided, the method incorporating antimalarial drugs such as quinine, quinidine, chloroquine, primaquine, and quinacrine as modulating compounds. In a preferred embodiment, the method is a fecal occult blood test (FOBT), in which a fecal specimen is contacted with a chromogen and a hydroperoxide in the presence of a selected quinoline derivative. The method enables careful modulation of test sensitivity and specificity, and further provides an FOBT in which interference from dietary meat ingestion is substantially eliminated.
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