Novel insulin peptides

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United States of America Patent

PATENT NO 4946828
SERIAL NO

07075387

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH, can be used to prepare solutions having prolonged insulin action. In the novel insulin derivatives, a basic amino acid has been substituted in the B27-position and/or a neutral amino acid has been inserted in the A4-, A17-, B13- and/or B21-position. Furthermore, the C-terminal carboxyl group of the B-chain may be blocked with an amido or ester residue.

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Patent Owner(s)

Patent OwnerAddress
NOVO NORDISK A/S A CORP OF DENMARKNOVO ALLE DK-2880 BAGSVAERD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Markussen, Jan Herlev, DK 25 607

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