Gonadoliberine analogues of high activity
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United States of America Patent
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Aug 14, 1990
Grant Date -
N/A
app pub date -
Oct 21, 1986
filing date -
Oct 22, 1985
priority date (Note) -
Expired
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Abstract
The present invention relates to novel gonadoliberine analogues of formula I Glp-His-Trp-Ser-X-W-Leu-Arg-Pro-Y (I) wherein X is Phe-, Tyr (3,5-.sup.3 H) or 3,5-dibromo-tyrosyl, W is Asu or Asp OR, wherein R is alkyl having 1 to 6 carbon atoms or phenyl or phenyl (alkyl having 1 to 4 carbon atoms), which latter two groups may optionally be substituted by nitro or one or more halogen atoms, and Y is glycinamide, aza-glycinamide or alkylamino having 1 to 4 carbon atoms, and acid-addition salts thereof, processes for preparing the same and pharmaceutical compositions comprising the same. The novel compounds have an influence on the sexual processes.
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