Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
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United States of America Patent
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Aug 14, 1990
Issued Date -
N/A
app pub date -
May 4, 1987
filing date -
Feb 22, 1983
priority date (Note) -
Expired
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Abstract
Substantially pure single-stranded oligonucleotides having a preselected sequence of not more than about 200 nucleotides, at least one of which is at a preselected position in the sequence and includes a base with a covalently attached linker arm containing or capable of binding at least one reporter group or solid support. A process for the chemical synthesis of the substantially pure single-stranded oligonucleotide and modified nucleosides useful in such synthesis are provided.
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