Feedback controlled release
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United States of America Patent
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Aug 28, 1990
Issued Date -
N/A
app pub date -
Apr 3, 1987
filing date -
Jun 27, 1985
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A controlled release system using a feedback-responsive controller reversibly changes the pH of the aqueous microenvironment of a biologically active compound sequestered in an aqueous-fluid-penetrable, aqueous-insoluble biocompatible material; the pH change is effected in response to a change in the concentration of the target compound in the aqueous medium surrounding the insoluble material; as a result of the pH change, the aqueous solubility and therefore the release rate of the active compound is reversibly changed.
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