Process for preparing N-sulphonyl-ureas

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United States of America Patent

PATENT NO 4954628
SERIAL NO

07317769

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Abstract

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The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) ##STR1## wherein Ar.sub.1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms, Ar.sub.2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C.sub.1-4 (halo)alkyl, C.sub.1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms. According to the invention N-halogen aryl sulphonamidate is reacted in the presence of a carbonylating catalyst, carbon monoxide and an aromatic amine, optionally in the presence of a phase transfer catalyst, or N-halogen aryl sulphonamidate is reacted with carbon monoxide in the presence of a carbonylating catalyst, and optionally in the presence of a phase transfer catalyst, then the obtained reaction mixture is further reacted with an aromatic amine or an N-halogen-arylamine-alkali metal salt is reacted with aryl-sulphonamid in the presence of a carbonylating catalyst, carbon monoxide and optionally in the presence of a phase transfer catalyst or an amine, amine dihalogenid, aryl sulphonamid are reacted in the presence of a carbonylating catalyst and carbon monoxide and the obtained reaction mixture is worked up in a known manner. The thus prepared sulphonyl-ureas are biologically active compounds, which are used in the pharmaceutical industry and for regulating plant growth.

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Patent Owner(s)

Patent OwnerAddress
NITROKEMIA IPARTELEPEK8184 FUZFOGYARTELEP
MAGYAR TUDOMANYOS AKADEMIA KOZPONTI KEMIAI KUTATO INTEZETE59-67 PUSZTASZERI UT BUDAPEST II

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Belak, Maria Budapest, HU 2 8
Besenyei, Gabor Budapest, HU 5 47
Dioszegine, Erzsebet E Veszprem, HU 2 8
Dukai, Jozsef Veszprem, HU 3 11
Nagy, Lajos Fuzfogyartelep, HU 42 208
Nemeth, Sandor Budapest, HU 8 38
Simandi, Laszlo Budapest, HU 7 48
Soptei, Csaba Veszprem, HU 10 28
Szabo, Maria Budapest, HU 3 7
Tomordi, Elemer Veszprem, HU 6 18

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