Method for separating the cellular components of blood samples

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 4957638
SERIAL NO

07349600

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An assembly for separating lymphocytes and monocytes from granulocytes in a sample of unseparated whole blood. A water insoluble, thixotropic gel-like substance, which is chemically inert to blood constituents is provided in a container. A fluid capable of altering blood cell densities and diameters is positioned above the surface of the water-insoluble thixotropic gel-like substance. Means for preventing the absorption of water by the thixotropic gel-like substance from the fluid and/or the sample of unseparated whole blood prior to separation are provided to substantially eliminate the influence of water absorption on the cell separation performance characteristics of said thixotropic gel-like substance. A method for separating lymphocytes and monocytes from granulocytes which inhibits the apparent shift of the buoyant density of the granulocytes and which substantially eliminates the influence of water absorption on the cell separation performance characteristics of the thixotropic gel-like substance is also disclosed.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BECTON, DICKINSON AND COMPANYFRANKLIN LAKES, NJ2057

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Smith, Ward C Mahwah, NJ 13 591

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Technicon Instruments Corporation (1)
* 4487700 Method and apparatus for separating lymphocytes from anticoagulated blood 28 1983
 
Ortho Diagnostic Systems, Inc. (2)
* 4435293 Particle washing system and method of use 26 1981
* 4436631 Multiple particle washing system and method of use 37 1982
 
SHERWOOD SERVICES AG (1)
* 4295974 Blood sample collection and phase separation device 30 1980
 
Sekisui Kagaku Kogyo Kabushiki Kaisha (2)
* 4457782 Composition for partitioning blood components 21 1981
* 4534798 Composition for partitioning blood components 13 1983
 
ASSAF SCIENTIFIC DEVELOPMENT CORPORATION LTD. (1)
* 4824560 Separation of materials from a liquid dispersion by sedimentation 38 1986
 
TERUMO KABUSHIKI KAISHA (1)
* 4310430 .alpha.-Olefin-dialkylmaleate-based liquid separating agent 25 1980
 
BECTON, DICKINSON AND COMPANY (5)
* 4417981 Blood phase separator device 109 1981
* 4640785 Separation of lymphocytes and monocytes from blood samples 23 1984
* 4816168 Separation of lymphocytes and monocytes from blood samples 33 1986
* 4844818 Method for separating the cellular components of blood samples 83 1987
* 4867887 Method and apparatus for separating mononuclear cells from blood 35 1988
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
* 2001/0007,315 Method and apparatus for dispensing separator gel in a blood collection tube 1 2001
 
Response Biomedical Corporation (1)
* 6046019 Diagnostic kits and methods for making granulocyte cell counts 13 1992
 
BIOMET BIOLOGICS, LLC (23)
7374678 Apparatus and method for separating and concentrating fluids containing multiple components 68 2004
7845499 Apparatus and method for separating and concentrating fluids containing multiple components 40 2006
7832566 Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles 26 2006
7914689 Apparatus and method for separating and concentrating fluids containing multiple components 32 2008
7780860 Apparatus and method for separating and concentrating fluids containing multiple components 27 2008
8012077 Blood separating device 7 2008
8337711 System and process for separating a material 4 2009
8187475 Method and apparatus for producing autologous thrombin 2 2009
8313954 All-in-one means of separating blood components 16 2009
9011800 Method and apparatus for separating biological materials 5 2009
8591391 Method and apparatus for separating a material 2 2010
8048321 Apparatus and method for separating and concentrating fluids containing multiple components 30 2010
8808551 Apparatus and method for separating and concentrating fluids containing multiple components 6 2010
8062534 Apparatus and method for separating and concentrating fluids containing multiple components 29 2010
8163184 Apparatus and method for separating and concentrating fluids containing multiple components 4 2011
8567609 Apparatus and method for separating and concentrating fluids containing multiple components 12 2011
8603346 Apparatus and method for separating and concentrating fluids containing multiple components 0 2011
8783470 Method and apparatus for producing autologous thrombin 6 2012
8992862 All-in-one means of separating blood components 5 2012
8801586 System and process for separating a material 7 2012
9239276 Apparatus and method for separating and concentrating fluids containing multiple components 0 2013
9533090 Method and apparatus for separating a material 0 2013
9114334 Apparatus and method for separating and concentrating fluids containing multiple components 0 2013
 
FENWAL, INC. (6)
7166231 Red blood cell separation method 25 2003
7297272 Separation apparatus and method 12 2004
8685258 Systems and methods for conveying multiple blood components to a recipient 2 2009
8075468 Systems and methods for mid-processing calculation of blood composition 14 2009
7918350 Separation apparatus and method 2 2009
7789245 Blood separation chamber 12 2009
 
COLEMAN, CHARLES M. (2)
* 5560830 Separator float and tubular body for blood collection and separation and method of use thereof 87 1994
* 5736033 Separator float for blood collection tubes with water swellable material 100 1996
 
CASCADE MEDICAL ENTERPRISES, LLC (6)
* 7745106 Methods and devices for separating liquid components 22 2003
* 2004/0071,786 Methods and devices for separating liquid components 12 2003
* 2008/0190,857 System and Methods of Producing Membranes 6 2006
8491564 Systems and methods for preparing autologous fibrin glue 0 2009
8802362 Methods and devices for separating liquid components 1 2010
* 2011/0020,196 METHODS AND DEVICES FOR SEPARATING LIQUID COMPONENTS 22 2010
 
DENDREON PHARMACEUTICALS, INC. (6)
* 5840502 Methods for enriching specific cell-types by density gradient centrifugation 135 1994
* 5648223 Methods for enriching breast tumor cells 50 1994
* 5646004 Methods for enriching fetal cells from maternal body fluids 72 1994
* 5577513 Centrifugation syringe, system and method 81 1994
* 5474687 Methods for enriching CD34.sup.+ human hematopoietic progenitor cells 75 1994
* 5663051 Separation apparatus and method 92 1995
 
HANUMAN LLC (16)
7824559 Apparatus and method for preparing platelet rich plasma and concentrates thereof 21 2006
7708152 Method and apparatus for preparing platelet rich plasma and concentrates thereof 33 2006
7866485 Apparatus and method for preparing platelet rich plasma and concentrates thereof 20 2007
7992725 Buoy suspension fractionation system 12 2008
7806276 Buoy suspension fractionation system 33 2008
7837884 Methods and apparatus for isolating platelets from blood 24 2008
7987995 Method and apparatus for preparing platelet rich plasma and concentrates thereof 15 2010
8119013 Method of separating a selected component from a multiple component material 10 2010
8096422 Apparatus and method for preparing platelet rich plasma and concentrates thereof 1 2010
8187477 Methods and apparatus for isolating platelets from blood 5 2010
8105495 Method for preparing platelet rich plasma and concentrates thereof 1 2011
8133389 Method and apparatus for preparing platelet rich plasma and concentrates thereof 8 2011
8328024 Buoy suspension fractionation system 4 2011
8596470 Buoy fractionation system 8 2012
8950586 Methods and apparatus for isolating platelets from blood 3 2013
9138664 Buoy fractionation system 0 2013
 
PLASMASEAL CORPORATION (2)
* 5788662 Methods for making concentrated plasma and/or tissue sealant 154 1996
* 6214338 Plasma concentrate and method of processing blood for same 113 2000
 
COVIDIEN AG (1)
6238578 Method for dispensing separator gel in a blood collection tube 16 1996
 
Biomet Biologies, LLC (1)
9556243 Methods for making cytokine compositions from tissues using non-centrifugal methods 0 2013
 
CLINICAL DIAGNOSTIC SYSTEMS INC. (1)
* 5364591 Device for moving a target-bearing solid through a liquid for detection while being contained 81 1992
 
Advanced Minerals Corporation (1)
* 6140040 Method of mechanically separating microparticles suspended in fluids using particulate media 23 1996
 
BECTON, DICKINSON AND COMPANY (2)
* 5494590 Method of using anticoagulant solution in blood separation 56 1992
* 5906744 Tube for preparing a plasma specimen for diagnostic assays and method of making thereof 39 1997
* Cited By Examiner