US Patent No: 4,957,638

Number of patents in Portfolio can not be more than 2000

Method for separating the cellular components of blood samples

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Abstract

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An assembly for separating lymphocytes and monocytes from granulocytes in a sample of unseparated whole blood. A water insoluble, thixotropic gel-like substance, which is chemically inert to blood constituents is provided in a container. A fluid capable of altering blood cell densities and diameters is positioned above the surface of the water-insoluble thixotropic gel-like substance. Means for preventing the absorption of water by the thixotropic gel-like substance from the fluid and/or the sample of unseparated whole blood prior to separation are provided to substantially eliminate the influence of water absorption on the cell separation performance characteristics of said thixotropic gel-like substance. A method for separating lymphocytes and monocytes from granulocytes which inhibits the apparent shift of the buoyant density of the granulocytes and which substantially eliminates the influence of water absorption on the cell separation performance characteristics of the thixotropic gel-like substance is also disclosed.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BECTON, DICKINSON AND COMPANYFRANKLIN LAKES, NJ2580

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Smith, Ward C Toms River, NJ 12 488

Cited Art Landscape

Patent Info (Count) # Cites Year
 
BECTON, DICKINSON AND COMPANY (7)
4,190,535 Means for separating lymphocytes and monocytes from anticoagulated blood 63 1978
4,350,593 Assembly, compositions and method for separating blood 51 1979
4,417,981 Blood phase separator device 88 1981
4,640,785 Separation of lymphocytes and monocytes from blood samples 22 1984
4,816,168 Separation of lymphocytes and monocytes from blood samples 29 1986
4,844,818 Method for separating the cellular components of blood samples 62 1987
4,867,887 Method and apparatus for separating mononuclear cells from blood 32 1988
 
Ortho Diagnostic Systems Inc. (2)
4,435,293 Particle washing system and method of use 25 1981
4,436,631 Multiple particle washing system and method of use 32 1982
 
Sekisui Kagaku Kogyo Kabushiki Kaisha (2)
4,457,782 Composition for partitioning blood components 21 1981
4,534,798 Composition for partitioning blood components 13 1983
 
ASSAF SCIENTIFIC DEVELOPMENT CORPORATION LTD. (1)
4,824,560 Separation of materials from a liquid dispersion by sedimentation 30 1986
 
SHERWOOD SERVICES AG (1)
4,295,974 Blood sample collection and phase separation device 27 1980
 
TECHNICON INSTRUMENTS CORPORATION (1)
4,487,700 Method and apparatus for separating lymphocytes from anticoagulated blood 25 1983
 
TERUMO KABUSHIKI KAISHA (1)
4,310,430 .alpha.-Olefin-dialkylmaleate-based liquid separating agent 23 1980
 
Other [Check patent profile for assignment information] (1)
4,255,256 Medium for the separation of human blood leucocytes 28 1979

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
BIOMET BIOLOGICS, LLC (17)
7,845,499 Apparatus and method for separating and concentrating fluids containing multiple components 21 2006
7,832,566 Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles 10 2006
7,914,689 Apparatus and method for separating and concentrating fluids containing multiple components 15 2008
7,780,860 Apparatus and method for separating and concentrating fluids containing multiple components 11 2008
8,012,077 Blood separating device 2 2008
8,337,711 System and process for separating a material 1 2009
8,187,475 Method and apparatus for producing autologous thrombin 1 2009
8,313,954 All-in-one means of separating blood components 5 2009
8,591,391 Method and apparatus for separating a material 0 2010
8,048,321 Apparatus and method for separating and concentrating fluids containing multiple components 12 2010
8,808,551 Apparatus and method for separating and concentrating fluids containing multiple components 0 2010
8,062,534 Apparatus and method for separating and concentrating fluids containing multiple components 16 2010
8,163,184 Apparatus and method for separating and concentrating fluids containing multiple components 0 2011
8,567,609 Apparatus and method for separating and concentrating fluids containing multiple components 3 2011
8,603,346 Apparatus and method for separating and concentrating fluids containing multiple components 0 2011
8,783,470 Method and apparatus for producing autologous thrombin 0 2012
8,801,586 System and process for separating a material 0 2012
 
HANUMAN LLC (14)
7,824,559 Apparatus and method for preparing platelet rich plasma and concentrates thereof 14 2006
7,708,152 Method and apparatus for preparing platelet rich plasma and concentrates thereof 19 2006
7,866,485 Apparatus and method for preparing platelet rich plasma and concentrates thereof 14 2007
7,992,725 Buoy suspension fractionation system 1 2008
7,806,276 Buoy suspension fractionation system 14 2008
7,837,884 Methods and apparatus for isolating platelets from blood 10 2008
7,987,995 Method and apparatus for preparing platelet rich plasma and concentrates thereof 6 2010
8,119,013 Method of separating a selected component from a multiple component material 1 2010
8,096,422 Apparatus and method for preparing platelet rich plasma and concentrates thereof 1 2010
8,187,477 Methods and apparatus for isolating platelets from blood 0 2010
8,105,495 Method for preparing platelet rich plasma and concentrates thereof 1 2011
8,133,389 Method and apparatus for preparing platelet rich plasma and concentrates thereof 4 2011
8,328,024 Buoy suspension fractionation system 0 2011
8,596,470 Buoy fractionation system 0 2012
 
DENDREON CORPORATION (6)
5,840,502 Methods for enriching specific cell-types by density gradient centrifugation 92 1994
5,648,223 Methods for enriching breast tumor cells 37 1994
5,646,004 Methods for enriching fetal cells from maternal body fluids 46 1994
5,577,513 Centrifugation syringe, system and method 53 1994
5,474,687 Methods for enriching CD34.sup.+ human hematopoietic progenitor cells 56 1994
5,663,051 Separation apparatus and method 77 1995
 
FENWAL, INC. (6)
7,166,231 Red blood cell separation method 12 2003
7,297,272 Separation apparatus and method 6 2004
8,685,258 Systems and methods for conveying multiple blood components to a recipient 0 2009
8,075,468 Systems and methods for mid-processing calculation of blood composition 3 2009
7,918,350 Separation apparatus and method 2 2009
7,789,245 Blood separation chamber 9 2009
 
CASCADE MEDICAL ENTERPRISES, LLC (3)
7,745,106 Methods and devices for separating liquid components 12 2003
8,491,564 Systems and methods for preparing autologous fibrin glue 0 2009
8,802,362 Methods and devices for separating liquid components 0 2010
 
BECTON, DICKINSON AND COMPANY (2)
5,494,590 Method of using anticoagulant solution in blood separation 47 1992
5,906,744 Tube for preparing a plasma specimen for diagnostic assays and method of making thereof 34 1997
 
COLEMAN, CHARLES M. (2)
5,560,830 Separator float and tubular body for blood collection and separation and method of use thereof 62 1994
5,736,033 Separator float for blood collection tubes with water swellable material 76 1996
 
PLASMASEAL CORPORATION (2)
5,788,662 Methods for making concentrated plasma and/or tissue sealant 122 1996
6,214,338 Plasma concentrate and method of processing blood for same 85 2000
 
ADVANCED MINERALS CORPORATION (1)
6,140,040 Method of mechanically separating microparticles suspended in fluids using particulate media 16 1996
 
BLOMET MANUFACTRUING CORP. (1)
7,374,678 Apparatus and method for separating and concentrating fluids containing multiple components 43 2004
 
CLINICAL DIAGNOSTIC SYSTEMS INC. (1)
5,364,591 Device for moving a target-bearing solid through a liquid for detection while being contained 60 1992
 
COVIDIEN AG (1)
6,238,578 Method for dispensing separator gel in a blood collection tube 13 1996
 
RESPONSE BIOMEDICAL CORPORATION (1)
6,046,019 Diagnostic kits and methods for making granulocyte cell counts 11 1992