Process for crosslinking of collagen by introduction of azide groups as well as tissues and biomaterials obtained by use of the process
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United States of America Patent
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Sep 18, 1990
Grant Date -
N/A
app pub date -
Jul 7, 1988
filing date -
Jul 8, 1987
priority date (Note) -
Expired
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Abstract
This process, which essentially comprises the following steps: esterification of the free acid groups of the collagen, transformation of the esterified groups into hydrazides groups, transformation of the hydrazide groups into azide groups by the action of nitrous acid, is characterized in that each step is separated by a rinsing in an aqueous salt solution, and in that the step of transformation of esterified groups into azide groups and the step of transformation of hydrazide groups into azide groups by the action of nitrous acid, are performed in the presence of salt.
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