Cysteine-depleted muteins of biologically active proteins
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United States of America Patent
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Sep 25, 1990
Issued Date -
N/A
app pub date -
Feb 7, 1985
filing date -
Nov 9, 1984
priority date (Note) -
Expired
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Abstract
Muteins of biologically active proteins such as IFN-.beta. and IL-2 in which cysteine residues that are not essential to biological activity have been deleted or replaced with other amino acids to eliminate sites for intermolecular crosslinking or incorrect intramolecular disulfide bridge formation. These muteins are made via bacterial expression of mutant genes that encode the muteins that have been synthesized from the genes for the parent proteins by oligonucleotide-directed mutagenesis.
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