US Patent No: 4,960,790

Number of patents in Portfolio can not be more than 2000

Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof

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Abstract

Derivatives of taxol represented by the formula ##STR1## wherein R and R' are each H or the residue of an amino acid selected from the group consisting of alanine, leucine, isoleucine, saline, phenylalanine, proline, lysine and arginine or a group of the formula ##STR2## wherein n is an integer of 1 to 3 and R.sup.2 and R.sup.3 are each hydrogen on an alkyl radical having from one to three carbon atoms or wherein R.sup.2 and R.sup.3 together with the nitrogen atom to which they are attached form a saturated heterocyclic ring having four to five carbon atoms, with the proviso that at least one of R and R.sup.1 is not hydrogen, are provided together with pharmaceutical compositions of such derivatives. The taxol derivatives have increased water solubility as compared to taxol, and have excellent antitumor activity.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
UNIVERSITY OF KANSASLAWRENCE, KS211
UNIVERSITY OF KANSAS, OFFICE OF RESEARCH GRADUATE STUDIES & PUBLIC SERVICE,LAWRENCE, KS1

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mathew, Abraham E Lenexa, KS 1 255
Stella, Valentino J Lawrence, KS 31 790

Cited Art

Patent Info (Count) # Cites Year
 
UNIVERSITY OF KANSAS, THE, LAWRENCE, KANSAS, A CORP. OF KANSAS (1)
4,650,803 Prodrugs of rapamycin 162 1985

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION (43)
5,384,399 Oxazinone compounds for the preparation of taxol 41 1992
5,350,866 10-desacetoxytaxol derivatives 69 1992
5,274,124 Metal alkoxides 67 1992
5,336,785 Method for preparation of taxol 53 1992
5,284,864 Butenyl substituted taxanes and pharmaceutical compositions containing them 53 1992
5,284,865 Cyclohexyl substituted taxanes and pharmaceutical compositions containing them 47 1992
5,283,253 Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them 90 1992
5,338,872 Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof 45 1993
5,430,160 Preparation of substituted isoserine esters using .beta.-lactams and metal or ammonium alkoxides 96 1993
5,466,834 Preparation of substituted isoserine esters using metal alkoxides and .beta. 65 1994
5,532,363 Heteroaryl substituted oxazinone compounds for the preparation of taxol 37 1994
5,539,103 .beta.-lactams as taxol intermediates N-acylated 44 1994
6,335,362 Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them 1 1995
5,728,850 Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them 14 1995
5,714,513 C10 taxane derivatives and pharmaceutical compositions 36 1995
5,723,634 Metal alkoxide compounds 19 1995
5,717,115 Metal alkoxides and ammonium alkoxides 12 1995
5,654,447 Process for the preparation of 10-desacetoxybaccatin III 12 1995
6,066,747 Process for the preparation of 9-desoxotaxanes 7 1995
5,760,219 Pyridyl substituted B-lactam compounds 9 1996
6,545,168 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof 0 1997
6,124,481 Ammonium alkoxides 7 1997
6,069,260 Metal alkoxides 10 1997
5,998,656 C10 tricyclic taxanes 3 1997
5,994,576 C7 tricyclic taxanes 0 1997
7,288,665 Process for selective derivatization of taxanes 1 1998
6,111,144 Method for the synthesis of a taxane intermediate 1 1998
6,191,287 Process for selective derivatization of taxanes 4 1999
6,462,208 C7 acyloxy and hydrido taxane derivatives and pharmaceutical compositions containing them 1 1999
6,479,678 Metal alkoxide taxane and .beta.-lactam compounds 3 2000
6,495,704 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes 1 2000
6,291,691 Process for selective derivatization of taxanes 1 2000
6,441,253 Method for the synthesis of taxanes 0 2000
6,706,896 Process for selective derivatization of taxanes 4 2000
6,630,609 Taxane synthesis method and intermediates 0 2002
6,710,191 9.beta.-hydroxytetracyclic taxanes 2 2002
6,620,950 Method for the preparation of 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs 1 2002
6,762,309 C7 acyloxy metal alkoxides 0 2002
6,683,196 Process for the preparation of metal alkoxides 0 2002
7,019,150 1-deoxy taxol analogs 0 2003
7,074,945 Metal alkoxide taxane derivatives 0 2003
6,878,834 14-hydrido-9.beta.-hydroxytetracyclic taxanes 1 2004
7,160,919 C7 lactyloxy-substituted taxanes 0 2005
 
SHIRE LLC (31)
6,716,452 Active agent delivery systems and methods for protecting and administering active agents 40 2000
7,018,654 Pharmaceutical composition containing an active agent in an amino acid copolymer structure 2 2001
7,163,918 Iodothyronine compositions 4 2002
7,060,708 Active agent delivery systems and methods for protecting and administering active agents 22 2002
7,223,735 Abuse resistant lysine amphetamine compounds 4 2004
7,105,486 Abuse-resistant amphetamine compounds 26 2004
7,622,441 Sustained release pharmaceutical compounds to prevent abuse of controlled substances 5 2004
7,427,600 Active agent delivery systems and methods for protecting and administering active agents 10 2004
7,375,082 Abuse-resistant hydrocodone compounds 4 2004
7,375,083 Pharmaceutical compositions for prevention of overdose or abuse 5 2004
7,338,939 Abuse-resistant hydrocodone compounds 4 2004
7,169,752 Compounds and compositions for prevention of overdose of oxycodone 5 2004
7,700,561 Abuse-resistant amphetamine prodrugs 1 2006
8,106,016 Compounds and compositions for prevention of overdose of oxycodone 0 2006
7,662,787 Abuse resistant lysine amphetamine compounds 0 2007
7,659,253 Abuse-resistant amphetamine prodrugs 0 2008
8,394,813 Active agent delivery systems and methods for protecting and administering active agents 0 2008
7,723,305 Abuse-resistant amphetamine prodrugs 0 2008
7,718,619 Abuse-resistant amphetamine prodrugs 0 2008
7,713,936 Abuse-resistant amphetamine prodrugs 0 2008
7,687,466 Abuse-resistant amphetamine prodrugs 0 2008
7,687,467 Abuse-resistant amphetamine prodrugs 0 2008
7,678,770 Abuse-resistant amphetamine prodrugs 1 2008
7,678,771 Abuse-resistant amphetamine prodrugs 0 2008
7,674,774 Abuse-resistant amphetamine prodrugs 0 2008
7,671,030 Abuse-resistant amphetamine prodrugs 0 2008
7,671,031 Abuse-resistant amphetamine prodrugs 0 2008
7,662,788 Abuse-resistant amphetamine prodrugs 0 2008
7,659,254 Abuse-resistant amphetamine prodrugs 0 2008
7,655,630 Abuse-resistant amphetamine prodrugs 0 2008
8,343,927 Pharmaceutical compositions for prevention of overdose or abuse 0 2010
 
BRISTOL-MYERS SQUIBB COMPANY (21)
5,272,171 Phosphonooxy and carbonate derivatives of taxol 87 1992
5,254,580 7,8-cyclopropataxanes 112 1993
5,294,637 Fluoro taxols 64 1993
H001487 Benzoate derivatives of taxol 0 1993
5,489,589 Amino acid derivatives of paclitaxel 21 1994
5,646,176 Phosphonooxymethyl ethers of taxane derivatives 45 1995
5,635,531 3'-aminocarbonyloxy paclitaxels 12 1996
5,840,929 C4 methoxy ether derivatives of paclitaxel 3 1996
6,455,575 Phosphonooxymethyl ethers of taxane derivatives 3 1997
5,773,464 C-10 epoxy taxanes 3 1997
5,977,386 6-thio-substituted paclitaxels 1 1997
5,912,264 6-halo-or nitrate-substituted paclitaxels 26 1998
5,902,822 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels 0 1998
6,017,935 7-sulfur substituted paclitaxels 3 1998
6,365,750 Methods for the preparation of taxanes using oxazolidine intermediates 1 1999
6,515,151 Method for the preparation of novel sidechain-bearing taxanes and intermediates thereof 4 2000
6,362,217 Taxane anticancer agents 0 2001
6,737,254 Supercritical extraction of taxanes 0 2001
6,906,040 Method for reducing toxicity of combined chemotherapies 0 2001
6,858,644 Paclitaxel solvates 4 2002
6,927,211 Method for reducing toxicity of combined chemotherapies 0 2003
 
INNOVATIONAL HOLDINGS LLC (20)
6,562,065 Expandable medical device with beneficial agent delivery mechanism 84 2000
6,855,125 Expandable medical device delivery system and method 30 2001
6,527,799 Expandable medical device with ductile hinges 76 2001
6,764,507 Expandable medical device with improved spatial distribution 66 2001
6,964,680 Expandable medical device with tapered hinge 21 2002
7,819,912 Expandable medical device with beneficial agent delivery mechanism 0 2003
7,056,338 Therapeutic agent delivery device with controlled therapeutic agent release rates 63 2003
7,179,288 Expandable medical device for delivery of beneficial agent 13 2003
7,169,179 Drug delivery device and method for bi-directional drug delivery 11 2003
7,896,912 Expandable medical device with S-shaped bridging elements 0 2004
7,517,362 Therapeutic agent delivery device with controlled therapeutic agent release rates 2 2004
8,187,321 Expandable medical device for delivery of beneficial agent 0 2005
7,850,727 Expandable medical device for delivery of beneficial agent 2 2005
7,850,728 Expandable medical device for delivery of beneficial agent 0 2006
8,361,537 Expandable medical device with beneficial agent concentration gradient 0 2007
8,052,734 Expandable medical device with beneficial agent delivery mechanism 0 2008
8,052,735 Expandable medical device with ductile hinges 0 2008
8,206,435 Expandable medical device for delivery of beneficial agent 0 2009
8,349,390 Method and apparatus for loading a beneficial agent into an expandable medical device 0 2010
8,197,881 Method and apparatus for loading a beneficial agent into an expandable medical device 0 2010
 
FSU RESEARCH FOUNDATION, INC. (11)
6,673,833 C7 heterosubstituted acetate taxanes 2 2001
6,664,275 C10 heterosubstituted acetate taxanes 2 2001
6,638,973 Taxane formulations 7 2001
6,610,860 C7 ester substituted taxanes 1 2001
6,359,154 C7 carbamoyloxy substituted taxanes 1 2001
6,750,245 C7 carbamate substituted taxanes 0 2002
7,186,849 C7 ester substituted taxanes 0 2003
6,872,837 Taxanes having a c10 Heterosubstituted acetate substituent 1 2003
6,861,446 C7 heterosubstituted acetate taxane compositions 0 2003
7,183,312 Taxanes having a C7 heterosubstituted acetate substituent 0 2005
7,157,474 C10 heterosubstituted acetate taxane compositions 0 2005
 
HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC. (11)
5,681,847 Methods of using discodermolide compounds 10 1995
5,840,750 Discodermolide compounds 6 1996
6,127,406 Discodermolide compounds and methods of use 8 1999
6,384,187 Antiproliferative activity of microsclerodermins 0 2000
6,576,658 Compositions and uses of dictyostatin compounds 0 2001
6,495,594 Biologically active analogs of discodermolide 5 2001
6,476,065 Discalamide compounds and their use as anti-proliferative agents 2 2001
6,677,370 Compositions and uses of dictyostatin compounds 0 2003
6,835,736 Discorhabdin compounds and methods of use 0 2003
7,053,118 Lactone compounds and methods of use 0 2003
6,852,754 Biologically active linderazulene terpenes 0 2004
 
MAYNE PHARMA (USA), INC. (9)
5,733,888 Injectable composition 46 1996
5,750,737 Method for paclitaxel synthesis 11 1996
6,133,462 C-7 CBZ baccatin III and production method therefor 3 1997
5,977,164 Stabilized pharmaceutical composition 12 1997
5,972,992 Injectable composition 18 1998
6,140,359 Injectable composition 5 1999
6,306,894 Injectable composition 3 2000
6,479,679 Two-step conversion of protected taxane ester to paclitaxel 1 2001
6,452,025 Three-step conversion of protected taxane ester to paclitaxel 0 2001
 
ENZON, INC. (8)
5,547,981 Taxol-7-carbazates 14 1994
5,622,986 2'-and/or 7-substituted taxanes 17 1994
5,614,549 High molecular weight polymer-based prodrugs 119 1995
5,686,110 Water soluble complex of an alkyl or olefinic end capped polyalkylene oxide and a water insoluble substance 15 1995
5,880,131 High molecular weight polymer-based prodrugs 71 1995
6,013,283 Alkyl or olefinic endcapped polyalkylene oxide solubilizer 3 1997
5,965,566 High molecular weight polymer-based prodrugs 43 1997
6,649,778 Methods of preparing amino acid taxane derivatives and polymer conjugates containing the same 10 2002
 
PG-TXL COMPANY, L.P. (7)
5,977,163 Water soluble paclitaxel prodrugs 156 1997
6,441,025 Water soluble paclitaxel derivatives 20 1998
6,262,107 Water soluble paclitaxel prodrugs 46 1999
6,884,817 Water soluble paclitaxel derivatives 12 2002
7,135,496 Water soluble paclitaxel derivatives 1 2002
7,060,724 Water soluble paclitaxel derivatives 7 2003
7,384,977 Water soluble paclitaxel prodrugs 0 2006
 
THE SCRIPPS RESEARCH INSTITUTE (6)
5,422,364 Water soluble taxol derivatives 46 1993
5,608,087 Water soluble taxol derivatives 8 1995
5,731,334 Method for treating cancer using taxoid onium salt prodrugs 6 1995
5,817,840 Water soluble taxol derivatives 12 1997
6,271,384 Self-assembled taxo-diterpenoid nanostructures 1 1998
6,252,094 Chemical switching of taxo-diterpenoids between low solubility active forms and high solubility inactive forms 3 1999
 
XECHEM INTERNATIONAL, INC. (6)
5,840,748 Dihalocephalomannine and methods of use therefor 0 1995
5,654,448 Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes 8 1995
5,854,278 Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents 0 1996
5,807,888 Preparation of brominated paclitaxel analogues and their use as effective antitumor agents 1 1996
5,840,930 Method for production of 2", 3" dihalocephalomannine 0 1996
6,177,456 Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor 2 1998
 
CEPHALON LIMITED (5)
5,580,899 Hydrophobic taxane derivatives 27 1995
6,118,011 Preparation of liposomal taxanes 2 1996
5,939,567 Synthesis of hydrophobic taxane derivatives 3 1997
6,291,690 Hydrophobic taxane derivatives 7 2000
6,392,063 Hydrolysis-promoting hydrophobic taxane derivatives 0 2000
 
PHARMACIA & UPJOHN COMPANY (5)
5,340,724 Use of taxol-dependent cells to identify and isolate taxol-like compounds 2 1991
5,821,363 Antineoplastic use and pharmaceutical compositions containing them 3 1996
6,057,452 Process to prepare taxol 2 1997
6,307,064 Process to prepare taxol 0 1999
6,177,573 Process to prepare taxol 0 1999
 
AVENTIS PHARMA S.A. (4)
5,438,072 Taxoid-based compositions 34 1993
5,698,582 Compositions containing taxane derivatives 19 1995
5,750,561 Compositions containing taxane derivatives 10 1995
5,714,512 Compositions containing taxane derivatives 10 1995
 
ANGIOTECH PHARMACEUTICALS, INC. (3)
5,886,026 Anti-angiogenic compositions and methods of use 181 1995
6,506,411 Anti-angiogenic compositions and methods of use 64 1999
7,820,193 Anti-angiogenic compositions and methods of use 0 2004
 
CONOR MEDSYSTEMS, INC. (3)
7,208,010 Expandable medical device for delivery of beneficial agent 19 2001
7,208,011 Implantable medical device with drug filled holes 61 2002
7,202,370 Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III 7 2003
 
PHYTON HOLDINGS, LLC (3)
5,336,684 Oxidation products of cephalomannine 16 1993
5,449,790 Preparation of 10-deacetylbaccatin III and 7-protected-10-deacetylbaccatin III derivatives from 10-deacetyl taxol A, 10-deacetyl taxol B, and 10-deacetyl taxol C 9 1994
5,364,947 Process for separating cephalomannine from taxol using ozone and water-soluble hydrazines or hydrazides 2 1994
 
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (3)
6,096,909 Taxoid anti-tumor agents and pharmaceutical compositions thereof 6 1997
6,458,976 Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods 3 1999
6,835,746 Taxoid anti-tumor agents and pharmaceutical compositions thereof 1 2002
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (3)
5,380,916 Method for the isolation and purification of taxane derivatives 15 1992
5,475,120 Method for the isolation and purification of taxol and its natural analogues 24 1994
5,670,673 Method for the isolation and purification of taxol and its natural analogues 11 1995
 
ACCORD HEALTHCARE LTD. (2)
5,981,564 Water-soluble derivatives of paclitaxel, method for producing same and uses thereof 10 1998
6,002,025 Method for the purification of taxanes 6 1999
 
CELL THERAPEUTICS, INC. (2)
7,173,041 Polyglutamic acid-camptothecin conjugates and methods of preparation 0 2003
7,153,864 Polyglutamic acid-camptothecin conjugates and methods of preparation 2 2003
 
E. R. SQUIBB & SONS, INC. (2)
5,567,614 Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes 32 1994
5,811,292 Lipase esterification processes for resolution of enantiomeric mixtures of intermediates in the preparation of taxanes 8 1996
 
GEORGETOWN UNIVERSITY (2)
5,424,073 Liposome encapsulated taxol and a method of using the same 26 1993
5,648,090 Liposome encapsulated toxol and a method of using the same 21 1995
 
INDENA SPA GRUPPO INVERNI DELLA BEFFA (2)
5,475,011 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment 46 1993
5,599,820 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment 13 1995
 
NEOPHARM, INC. (2)
7,314,637 Method of administering liposomal encapsulated taxane 0 1999
8,298,573 Stable sterile filterable liposomal encapsulated taxane and other antineoplastic drugs 0 2005
 
NITROMED, INC. (2)
6,656,966 Nitrosated and nitrosylated taxanes, compositions and methods of use 17 2001
6,869,973 Nitrosated and nitrosylated taxanes, compositions and methods of use 3 2003
 
TANABE SEIYAKU CO., LTD. (2)
5,677,470 Baccatin derivatives and processes for preparing the same 10 1995
5,608,073 Baccatin derivatives and processes for preparing the same 3 1996
 
THE UNIVERSITY OF BRITISH COLUMBIA (2)
7,067,494 Antimitotic eleuthesides 0 2002
8,324,410 Modified drugs for use in liposomal nanoparticles 0 2012
 
THE UPJOHN COMPANY (2)
5,556,878 .DELTA..sup.6,7 -taxols antineoplatic use and pharmaceutical compositions containing them 30 1994
5,965,739 .DELTA..sup.6,7 -taxols antineoplastic use and pharmaceutical compositions containing them 25 1995
 
THOMAS JEFFERSON UNIVERSITY (2)
5,356,927 Methods of treating plasmodium and babesia parasitic infections 9 1992
5,631,278 Methods of killing protozoal parasites 5 1995
 
ANGIOTECH BIOCOATINGS CORP. (1)
5,716,981 Anti-angiogenic compositions and methods of use 590 1995
 
BAKER NORTON PHARMACEUTICALS, INC. (1)
6,964,946 Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same 2 1998
 
BIONATURE E.A. LIMITED (1)
7,358,379 Steroid conjugates, preparation thereof and the use thereof 0 2006
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
5,508,447 Short synthetic route to taxol and taxol derivatives 12 1994
 
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (1)
5,279,949 Process for the isolation and purification of taxol and taxanes from Taxus spp 35 1992
 
CONOR MEDSYSTEMS, LLC. (1)
7,909,865 Expandable medical device for delivery of beneficial agent 0 2009
 
HEMAGEN/PFC (1)
5,616,330 Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same 30 1994
 
HOFFMANN-LA ROCHE INC. (1)
5,824,698 Antibacterial dibenzimidazole derivatives 15 1997
 
INDENA SPA OF VIALE ORTLES (1)
5,705,508 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment 20 1995
 
MANGO HEALTH BENEFITS CORPORATION (1)
7,025,994 Dietary compounds useful for the reduction of pathological conditions and the promotion of good health 0 2002
 
MEDIXIS, S.A. (1)
7,495,115 Steroid conjugates, preparation thereof and the use thereof 1 2003
 
MONTANA STATE UNIVERSITY (1)
5,916,783 Taxol production by a microbe 3 1997
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
6,150,398 Methods for the treatment of cancer 3 1996
 
PHARMACIA & UPJOHN S.P.A. (1)
5,362,831 Polymer-bound paclitaxel derivatives 86 1993
 
PROTHERICS SALT LAKE CITY, INC. (1)
7,649,023 Biodegradable block copolymeric compositions for drug delivery 1 2002
 
RESEARCH FOUNDATION STATE UNIVERSITY OF NEW YORK, THE (1)
5,294,737 Process for the production of chiral hydroxy-.beta.-lactams and hydroxyamino acids derived therefrom 24 1992
 
RHONE-POULENC RORER S.A. (1)
5,403,858 New compositions containing taxane derivatives 51 1993
 
SANOFI (1)
6,911,549 Method of preparing a taxol derivative 1 1993
 
SYNPLICITY, INC. (1)
6,500,858 Taxoid anti-tumor agents and pharmaceutical compositions thereof 2 2001
 
TANABLE SEIYAKU, CO., LTD (1)
5,589,502 Baccatin derivatives and processes for preparing the same 7 1995
 
TAPESTRY PHARMACEUTICALS, INC. (1)
5,688,977 Method for docetaxel synthesis 27 1996
 
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (1)
6,080,777 Taxol as a radiation sensitizer 5 1994
 
THE UAB RESEARCH FOUNDATION (1)
6,191,290 Taxane derivatives for targeted therapy of cancer 19 2000
 
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (1)
6,593,334 Camptothecin-taxoid conjugates as antimitotic and antitumor agents 0 2002
 
TRANSFORM PHARMACEUTICALS, INC. (1)
6,919,370 Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof 7 2001
 
UNIVERSITY OF KANSAS (1)
5,672,584 Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability 27 1995
 
UNIVERSITY OF PORTLAND (1)
6,638,742 Methods for obtaining taxanes 2 2001
 
VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY (1)
5,411,984 Water soluble analogs and prodrugs of taxol 14 1992
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (3)
5,192,796 Fluoro taxols 1992
H1487 Benzoate derivatives of taxol 2 1993
8,439,968 Expandable medical device for delivery of beneficial agent 0 2011