Oral sustained release acetaminophen formulation and process
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United States of America Patent
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-
Nov 6, 1990
Issued Date -
N/A
app pub date -
Jan 19, 1989
filing date -
Jul 27, 1987
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
An acetaminophen-sustained release tablet or tablet layer is formed by making a wet granulation, using Povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with acetaminophen, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promoter, e.g. pregelatinized starch, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the acetaminophen.
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