Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith
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United States of America Patent
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Nov 13, 1990
Grant Date -
N/A
app pub date -
Jan 3, 1989
filing date -
Jan 3, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An aqueous-based formulation for coating aspirin granules to provide granules that may be compressed into tablets and that show approximately zero-order release kinetics for release rates of 5 to 15 mg/hour over a period extending five to eight hours is provided. The coating formulation preferably consists of an acrylate/methacrylate copolymer, hydroxypropylmethylcellulose, sodium chloride and talc. A film-coated tablet comprised of the coated granules, filler granules, excipients, binders and disintegrants is also provided, as are processes for preparing the tablets and granules and methods for their use in the treatment of vascular occlusive diseases.
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