Diagnostic probe for rheumatoid arthritis predisposition
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United States of America Patent
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Nov 20, 1990
Grant Date -
N/A
app pub date -
Oct 30, 1987
filing date -
Oct 30, 1987
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Oligonucleotide probes for diagnosing predisposition to rheumatoid arthritis, capable of specifically hybridizing with 5'-TACGGGGTTGR.sub.1 GAGAGCTT-3' or 3'-AR.sub.2 GCCCCAACR.sub.3 CR.sub.2 CR.sub.2 CGAA-5' wherein A is adenine, C is cytosine, G is guanine, T is thymine, R.sub.1 is GT or TG, R.sub.2 is T or uracil, and R.sub.3 is CA or AC. Or, capable of specifically hybridizing with 5'-GGAGCAGAR.sub.2 GCGGGCCGCGG-3' or 3'-CCR.sub.2 CGR.sub.2 CR.sub.2 R.sub.3 CGCCCGGCGCC-5' wherein R.sub.1 is A or G, R.sub.2 is T or uracil, and R.sub.3 is R.sub.2 or C.
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