Method to derivatize dextran
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United States of America Patent
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Dec 4, 1990
Issued Date -
N/A
app pub date -
Dec 24, 1987
filing date -
Nov 28, 1986
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method to convert the hydroxyl groups of solubilized dextran to the tresylate forms which can be displaced by a nucleophile is disclosed. The method of the invention requires the reaction of dextran with the tresylating reagent in the presence of dry DMSO. The resulting tresylate can be converted to labeled dextrans which have direct linkages of a nucleophilic label to the carbons of the dextran backbone.
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