Prevention of prosthesis calcification
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United States of America Patent
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Dec 11, 1990
Issued Date -
N/A
app pub date -
Jan 27, 1989
filing date -
Feb 3, 1988
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method for retarding or preventing the calcification of a prosthesis implanted in a mammal by covalently coupling to the prosthesis before implantation an effective amount of an anticalcification agent in the form of an aliphatic carboxylic acid, or a derivative thereof, which contains from about 8 to about 30 carbon atoms and which may be straight-chain or branched-chain and saturated or unsaturated. Such acid is substituted by at least one amino, mercapto, carboxyl or hydroxyl group by which the covalent coupling takes place. For a natural tissue prosthesis, such coupling may be to an aldehyde group of gluteraldehyde in which the tissue is pre-soaked.
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