Orally administerable ANF
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United States of America Patent
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-
Jan 8, 1991
Grant Date -
N/A
app pub date -
Feb 24, 1989
filing date -
Feb 24, 1989
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Atrial naturiuretic factor (ANF) is encapsulated within hollow acidic proteinoid microspheres which are stable and protective in the acidic stomach of a mammal but which dissolve at the near neutral pH of the blood. Microspheres having diameters of less than about 10 microns readily penetrate the gastrointestinal mucosa and release the ANF in the bloodstream in physiologically active form. Such gastric administration significantly extends the period of effectiveness of ANF as a diuretic and blood pressure suppressant.
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