External preparations of melanogenesis-inhibitory agent
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United States of America Patent
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-
Jan 15, 1991
Grant Date -
N/A
app pub date -
Apr 18, 1988
filing date -
Jun 27, 1986
priority date (Note) -
Expired
status (Latency Note)
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Abstract
External preparations of 1 melanogenesisinhibitory agent contain, as active ingredients, a placental extract of pregnant cows and kojic acid or a derivative thereof. The placental extract of pregnant cows is a very effective melanogenesis-inhibitory substance, which acts through a mechanism different from that of the known extract of fully-matured human placenta and markedly diminishes the overall activity of tyrosinase isozymes (T.sub.1, T.sub.2 and T.sub.3). The external preparations, which utilize the synergistic effect between this unique substance and kojic acid or a derivative thereof (a known melanogensis-inhibitory substance), are effective for the relief and prevention of pigmentation diseases, such as liver spots.
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