Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs

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United States of America Patent

PATENT NO 4990538
SERIAL NO

07397551

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention relates to the use of a compound comprising toremifene or its metabolites N-demethyltoremifene or 4-hydroxytoremifene or its non-toxic pharmaceutically acceptable salts for the reversal of multidrug resistance of cancer cells to cytotoxic drugs in the treatment of cancer with such cytotoxic drugs.

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Patent Owner(s)

  • ORION CORPORATION;YALE UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DeGregorio, Michael W 93 Leatherman Trail, Hamden, CT 06518 10 120
Harris, Adrian L 83 Kingston Road, Oxford OX2 64J, GB3 12 78
Kangas, Lauri V M Pasantie 3 B, 21280 Raisio, FI 7 283

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