Transdermal acrylic multipolymer drug delivery system
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United States of America Patent
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-
Feb 19, 1991
Issued Date -
N/A
app pub date -
Jan 11, 1989
filing date -
Mar 4, 1988
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A dermal composition comprising a drug, a multipolymer of ethylene-vinyl acetate, an acrylic polymer, and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably, 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multipolymer, drug and optional crosslinking agent and additional ingredients in solution or suspension or emulsion followed by removal of excess solvent.
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