Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system

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United States of America Patent

PATENT NO 4996041
SERIAL NO

07234339

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Abstract

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A diagnostic imaging agent is provided for use in conjunction with a magnetic resonance imaging system for the imaging of spacial oxygen distribution in tissue. The imaging agent is comprised of a complex of oxygen-17, a biologically acceptable liquid carrier, such as a perfluorinated compound, and an emulsifying agent, and wherein the agent has an average particle size of less than about 0.6 microns, and an ionic composition essentially equal to that of blood. Useful information can be obtained, and in certain instances, therapy administered, by a non-envasive imaging technique relative to tissue perfusion by .sup.19 F-NMR (imaging of .sup.19 F) and oxygen utilization by .sup.1 H-NMR (imaging of H.sub.2.sup.17 O as a metabolite).

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Patent Owner(s)

Patent OwnerAddress
ARAI TOSHIYUKINot Provided

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arai, Toshiyuki 26-46 Nishifukunokawa-cho, Okazaki, Sakyo-ku, Kyoto 606, JP 49 727
Gupte, Pradeep M 3 Larissa Ct., Tallman, Monsey, NY 10952 5 298
Lasker, Sigmund E 531 Main St., New York, NY 10044 8 202

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