pH-sensitive immunoconjugates and methods for their use in tumor therapy
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United States of America Patent
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Mar 5, 1991
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N/A
app pub date -
May 12, 1987
filing date -
Jun 30, 1986
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Expired
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Abstract
Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid. Representative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells.
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