Method for monitoring glucose
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United States of America Patent
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Mar 19, 1991
Issued Date -
N/A
app pub date -
Jul 31, 1990
filing date -
Jun 26, 1986
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method for monitoring the glucose level in a body fluid uses an apparatus which includes a conjugate of glucose oxidase and a fluorescent dye coated onto an optical fiber in contact with the body fluid, a source of excitation light and a fluorescence emission detector. Glucose is oxidized by oxygen in the body fluid causing a decrease in oxygen concentration at the enzyme. The fluorescent dye is sensitive to oxygen quenching so that, when the oxygen concentration decreases, fluorescence emission increases in direct proportion to the glucose concentration in the fluid.
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