Specific ligands for estrogen and progestagen steroid hormone receptors, application and intermediate synthesis products
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United States of America Patent
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Mar 26, 1991
Grant Date -
N/A
app pub date -
Oct 18, 1989
filing date -
Oct 19, 1988
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The present invention relates to specific ligands for estrogen or progestagen steroid hormone receptors which have the formula ##STR1## in which X denotes a vinyl group substituted by a radioactive or nonradioactive halogen on the double bond according to a Z isomerism, and Y denotes either a hydroxyl group, in which case the ring to which it is attached is an aromatic ring, or a ketone functional group, in which case it is conjugated with a double bond at C.sub.4 -C.sub.5. An application of the ligands according to the invention is the targeted therapy and/or medical imagery, especially of cancer. However, these ligands can also be employed in the quantitative determination of said hormone receptors. However, the labeled ligands according to the invention are of very particular interest in the case of the targeted radiotherapy of cancer.
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