Pro-liposome compositions
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United States of America Patent
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Apr 2, 1991
Issued Date -
N/A
app pub date -
Mar 21, 1988
filing date -
Mar 8, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Pro-liposome compositions comprise membrane lipids such as lecithin or distearyl dimethylammonium chloride, water-miscible solvents such as ethanol, optionally a minor proportion of water, and optionally fatty acid esters and drugs. On addition to excess water they spontaneously form dispersions of liposomes having high void volumes and high drug entrapment ratios. Aerosol compositions are presented in a volatile liquid propellant. On being sprayed they form an aerosol of droplets which, on contact with aqueous media, spontaneously form liposome dispersions.
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