Oral sustained release pharmaceutical formulation and process
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United States of America Patent
Stats
-
Apr 2, 1991
Issued Date -
N/A
app pub date -
Aug 11, 1989
filing date -
Jul 27, 1987
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a pharmaceutical active, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promotor, e.g. pregelantinized starch, additional wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the pharmaceutical active.
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