Novel benzazepine derivatives

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United States of America Patent

PATENT NO 5010074
SERIAL NO

07365250

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Abstract

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Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl; R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --; R.sup.7 represent hydroxy, lower alkoxy; R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or alkoxy or trifluoromethyl, or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among --O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-CH.dbd.CH--, --CH.sub.2 -CH.sub.2 -CH.sub.2 --, --CH.sub.2 -CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --; R.sup.13 represents hydrogen, halogen or lower alkyl. The compounds are useful in preparations for treatment of disorders in the central nervous system.

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ADDEX PHARMACEUTICALS SAPLAN-LES-OUATES GENÈVE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Andersen, Peter H Vanlse, DK 6 13
Faarup, Peter Vaerlose, DK 23 324
Gronwald, Frederik Vedbaek, DK 2 2
Guddal, Erling Brondby, DK 11 85
Hansen, Kristian T Kobenhavn, DK 4 12
Hansen, Louis B Vaerlose, DK 7 15
Nielsen, Erik B Vaerlose, DK 4 9

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