Antibody-drug conjugates
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United States of America Patent
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Apr 23, 1991
Grant Date -
N/A
app pub date -
Nov 10, 1988
filing date -
Nov 10, 1988
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Modified antibodies or antigen-recognizing fragments are prepared with a linker consisting of a malonate, wherein the antibody or fragment thereof is attached through a carbonyl to an ester or amide group on one of the malonate carboxyls, and the drug is linked through a methylene to the 2-position carbon of the malonate.
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