Novel derivatives of 6,11-dihydro-dibenzo(C,F)(1,2,5)-thiadiazepine 5,5-dioxide, salts thereof and appropriate processes for the preparation thereof
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United States of America Patent
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Apr 30, 1991
Grant Date -
N/A
app pub date -
Aug 11, 1989
filing date -
Aug 12, 1988
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Novel derivatives of 11-carbonyl-6,11-dihydrodibenzo[c,f][1,2,5]thiadiazepine 5,5-dioxide of the general formula ##STR1## wherein R and R.sub.1, which can be different, represent a hydrogen atom or a (C.sub.1 -C.sub.5) alkyl or (C.sub.1 -C.sub.4)hydroxyalkyl group, or R and R.sub.1 together can form a 5-membered and/or 6-membered heterocyclic ring which may contain a further heteroatom, R.sub.2 and R.sub.3, which can be different, represent a hydrogen atom, a (C.sub.1 -C.sub.3)alkoxy, (C.sub.1 -C.sub.3)alkyl, nitro, amino or (C.sub.1 -C.sub.3)alkylamino, halogen, halogeno-alkyl or hydroxyl group, R.sub.4 represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl, alkylaryl or (C.sub.1 -C.sub.6)alkylamino group, and n assumes values of 0, 1 or 2, and non-toxic, pharmaceutically acceptable salts thereof, obtained by addition of acids or alkyl halides.
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