Antihypercholesterolemic alkylene compounds
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United States of America Patent
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Apr 30, 1991
Issued Date -
N/A
app pub date -
Jun 12, 1990
filing date -
Aug 25, 1988
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl; R is C.sub.1-7 alkyl, C.sub.3-6 cycloalkyl, fluoromethyl, difluoromethyl, trifluoromethyl; A is ##STR2## R.sup.5 is hydrogen, a hydrolyzable ester group or a cation to form a non-toxic pharmaceutically acceptable salt, are novel antihypercholesterolemic agents which inhibit cholesterol biosynthesis. Intermediates and processes for their preparation are disclosed.
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