Liposomes with enhanced circulation time
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United States of America Patent
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May 7, 1991
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N/A
app pub date -
Oct 20, 1989
filing date -
Oct 20, 1989
priority date (Note) -
Expired
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Abstract
A liposome composition which contains between 1-20 mole percent of an amphipathic lipid derivatized with a polyalkylether, as exemplified by phosphatidylethanolamine derivatized with polyethyleneglycol. The derivatized lipid enchances the circulation time of the liposomes severalfold, and this enhancement is achieved with either fluid or membrane-rigidifying liposome components. Also disclosed are methods for delivering a drug for slow release from the bloodstream, and for targeting a selected tissue or cells with liposomes, via the bloodstream.
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