Taste masking compositions comprising spray dried microcapsules containing sucralfate and methods for preparing same
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United States of America Patent
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May 7, 1991
Grant Date -
N/A
app pub date -
Oct 3, 1989
filing date -
Oct 3, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention pertains to spray dried spheroidal microcapsules under about 150 microns in diameter which comprise in percentages by weight of the microcapsule composition (a) sucralfate present in an amount from about 1% to about 70%, and (b) a polymer soluble in the gastric fluids present in an amount from about 30% to about 99%. In another embodiment, the invention is directed at a taste masking composition which comprises a therapeutically effective amount of a spray dried spheroidal microcapsule core under about 150 microns in diameter and a matrix over the core wherein the taste masking composition comprises (A) a microcapsule core comprising in percentages by weight of the core composition (a) sucralfate present in an amount from about 1% to about 70%, and (b) a polymer soluble in the gastric fluids present in an amount from about 30% to about 99%; and (B) a matrix over the core comprising in percentages by weight of the matrix composition (a) a bulking agent present in an amount up to about 99.9%, and (b) a lubricating agent present in an amount from about 0.1% to about 7%.
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