Efficient method for preparation of prolonged release liposome-based drug delivery system

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United States of America Patent

PATENT NO 5023087
SERIAL NO

07326198

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Abstract

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A method for selectively controlling the rate of release of a liposome-entrapped compound from an intramuscular or subcutaneous injection site. The method includes selecting the average size, amount, and lipid composition of liposomes injected into the site to produce a desired half-life of release of the compound. A preferred composition used in practicing the invention includes an aqueous suspension of liposomes containing the compound in entrapped form, and having average particle sizes less than about 0.2 microns, and large amount of larger empty lipsomes present in an amount effective to increase the half-life of release of the compound from the injection site to a desired half-life between about 1-14 days.

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Patent Owner(s)

Patent OwnerAddress
LIPOSOME TECHNOLOGY INC A CORP OF CA1050 HAMILTON COURT MENLO PARK CA 94025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Yau-Young, Annie Los Altos, CA 8 1916

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