Oligonucleotide therapeutic agent and method of making same
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United States of America Patent
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Jun 11, 1991
Issued Date -
N/A
app pub date -
May 15, 1989
filing date -
Oct 23, 1981
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Expired
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Abstract
For use in controlling biologic functions in an organism, a stabilized oligonucleotide, preferably in a phosphotriester form, having a base sequence substantially complementary to a portion of messenger ribonucleic acid coding for a biological component, such as a protein, of the organism. The oligonucleotide has about fourteen bases or more, such as twenty-three bases, and can be a deoxyribonculeotide. The oligonucleotide sequence can be derived from the organism's ribonucleic or deoxyribonucleic acid that codes for a vital protein, and can be synthesized in bulk either chemically or by insertion into a plasmid.
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