Nicotinic acid derivatives and pharmaceutical compositions comprising same

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United States of America Patent

PATENT NO 5025012
SERIAL NO

07484130

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compounds are disclosed of the formula ##STR1## wherein R.sub.1 is hydrogen or C.sub.1 -C.sub.6 alkyl; Y is --CH.sub.2 --, --O--, ##STR2## R.sub.2 is C.sub.1 -C.sub.6 alkyl; C.sub.2 -C.sub.6 alkenyl; C.sub.3 -C.sub.6 cycloalkyl; phenyl which may be mono- or di-substituted on the phenyl ring with C.sub.1 -C.sub.6 alkoxy; aralkyl which may be mono- or di-substituted on the aromatic ring with C.sub.1 -C.sub.6 alkoxy; diphenylmethyl; carboalkoxy; or an O- or N-heterocyclic radical which is linked to the nitrogen atom via carbonyl or carbonylmethylene; m is 2 or 3; and n is 0 or 1, and physiologically acceptable acid addition salts thereof. The compounds of formula (I) are of a blood flow-increasing action and can be used for the therapy or prevention of diseases in the cardiovascular system.

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Patent Owner(s)

  • NISSHIN SEIFUN GROUP INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Koyama, Hiroyasu Saitama, JP 45 246
Miura, Katsutoshi Saitama, JP 5 171
Sakurai, Einosuke Saitama, JP 8 90
Sugai, Toshiji Saitama, JP 10 76
Yamada, Hiroaki Saitama, JP 153 1053

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