Electrolytic transdermal delivery of polypeptides
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United States of America Patent
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Jul 16, 1991
Issued Date -
N/A
app pub date -
Nov 1, 1989
filing date -
Feb 10, 1987
priority date (Note) -
Expired
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Abstract
The invention comprises in combination: (a) a polypeptide having from about three to about 20 peptide units in aqueous solution or suspension, and (b) an electrolytic device for transdermal transport of the polypeptide to the bloodstream of the patient. It may be useful to enhance the transdermal delivery of the polypeptide by adding an aqueous cosolute/cosolvent with negative Setschenow constants. The electrolytic device preferably comprises a hydrophilic reservoir containing a supply of the aqueous polypeptide solution or suspension, an electric battery, two extended contacts, and optionally a semipermeable membrane between the reservoir and the patient's skin. Representative polypeptides include oxytocin, angiotensin I, II, and III, substance P, vasopressin, lypressin, desmopressin, leuprolide acetate, antripeptin, and the like.
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