Process for producing compounds containing a terminal hydroxyl or epoxy group and microorganisms suitable therefor
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United States of America Patent
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Jul 16, 1991
Grant Date -
N/A
app pub date -
Jan 14, 1988
filing date -
Jan 15, 1987
priority date (Note) -
Expired
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Abstract
This invention relates to a process for the microbiological production of compounds containing a terminal hydroxyl or epoxy group from an aliphatic substrate or a substrate with an aliphatic side chain, using microorganisms genetically engineered so that they have retained their capacity to perform the terminal oxidation of the substrate, but are no longer able to convert the resulting oxidation product further to any significant extent. Preferred substrates are n-alkanes, n-alkenes, and n-alkadienes containing 6-12 carbon atoms. Preferred micro-organisms are genetically engineered Pseudomonas oleovorans and Pseudomonas putida strains lacking an active plasmidic alkanol-dehydrogenase gene. The invention also relates to micro-organisms thus genetically engineered.
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