Uncharged morpholino-based polymers having achiral intersubunit linkages
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United States of America Patent
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Jul 23, 1991
Issued Date -
N/A
app pub date -
Dec 20, 1989
filing date -
Mar 15, 1985
priority date (Note) -
Expired
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Abstract
A polymer composition is disclosed composed of morpholino subunit structures which are linked together by uncharged, achiral linkages. These linkages are one to three atoms in length, joining the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
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