Diagnostic probe for diabetes type I predisposition
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United States of America Patent
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Aug 13, 1991
Grant Date -
N/A
app pub date -
Oct 29, 1987
filing date -
Oct 29, 1987
priority date (Note) -
Expired
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Abstract
An oligonucleotide probe for diagnosing predeposition or susceptibility to type I diabetes, capable of specifically hybridizing with the gene sequence 3'-GCGGGCRARGRGGGGRGCAG-5' or 5'-CGCCCGATACACCCCACGTC-3' wherein A is adenine, C is cytosine, G is guanine, T is thymine, and R is thymine or uracil. The probe may include at least 15 sequential nucleotides selected from the sequence 5'-GCCCGATACACCCCCACGT-3' or 3'-CGGGCRARGRGGGGGRGCA-5' The probe may be labeled with a detectable marker, such as an enzyme or biotin, and may be supplied in a diagnostic kit in combination with: a substratum capable of absorbing DNA or cells, a restriction enzyme, and/or a detergent.
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