Method and nucleic acid for the preparation of lecithin:cholesterol acyltransferase
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United States of America Patent
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Sep 17, 1991
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N/A
app pub date -
Nov 8, 1985
filing date -
Nov 8, 1985
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Expired
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Abstract
Nucleic acid encoding lecithin:cholesterol acyltransferase is ligated into expression vectors and used to transform host cells for the synthesis of lecithin:cholesterol acyltransferase in recombinant cell culture. Lecithin:cholesterol acyltransferase amino acid sequence variants are described for enhancing the properties of lecithin:cholesterol acyltransferase. Lecithin:cholesterol acyltransferase and its variants are employed in the therapy of conditions characterized by hypercholesterolemia and for the mobilization of cholesterol in vivo.
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