Compositions for photodynamic therapy
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United States of America Patent
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Oct 1, 1991
Grant Date -
N/A
app pub date -
Mar 22, 1990
filing date -
Mar 22, 1990
priority date (Note) -
Expired
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Abstract
Porphyrin-type photosensitizers useful in photodynamic therapy can be formulated as water soluble drugs by conjugation of the photosensitizer to a hydrophilic polymer. Conjugation of the photosensitizer in varying ratios to the polymer, such as polyvinyl alcohol, provides compositions which are readily soluble and biodistribute in a fashion equal to or advantageous over that obtained when the photosensitizer is administered alone. In addition, these conjugates which further a contain target specific component provide a mechanism for homing to the desired target tissue, as well as offering a convenient approach to including both target specific component and photosensitizing drug in the same complex.
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